Spatial and temporal control of RNA stability
Spatial and temporal control of RNA stability
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DOI：
10.1073/pnas.111145698
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发表时间：
2001-06-19
影响因子：
11.1
通讯作者：
Lipshitz, HD
中科院分区：
文献类型：
--
作者：
Bashirullah, A;Cooperstock, RL;Lipshitz, HD
母性编码的RNA和蛋白质决定了所有动物的早期发育。在中期胚泡转变之前，母体转录子集从胚胎中被消除。在某些情况下，转录产物在胚胎细胞质的某个分区中受到保护，不会被降解。从而导致转录本地化。母体因素对转录本本地化的降解和保护部分都是足够的。RNA中的顺式作用元件逐渐地将转录本转化为(I)从固有稳定到不稳定和(Ii)从均匀降解到局部保护的转录本。类似的机制可能会在发育后期发挥作用，将某些类别的转录本限制在体细胞谱系中的特定细胞类型。讨论了转录本的降解和保护功能。
Maternally encoded RNAs and proteins program the early development of all animals. A subset of the maternal transcripts is eliminated from the embryo before the midblastula transition. In certain cases, transcripts are protected from degradation in a subregion of the embryonic cytoplasm. thus resulting in transcript localization. Maternal factors are sufficient for both the degradation and protection components of transcript localization. Cis-acting elements in the RNAs convert transcripts progressively (i) from inherently stable to unstable and (ii) from uniformly degraded to locally protected. Similar mechanisms are likely to act later in development to restrict certain classes of transcripts to particular cell types within somatic cell lineages. Functions of transcript degradation and protection are discussed.