A rapid and simple extraction of anti-depressant drugs by effervescent salt-assisted dispersive magnetic micro solid-phase extraction method using new adsorbent Fe3O4@SiO2@N3
A rapid and simple extraction of anti-depressant drugs by effervescent salt-assisted dispersive magnetic micro solid-phase extraction method using new adsorbent Fe3O4@SiO2@N3
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DOI：
10.1016/j.aca.2018.10.028
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发表时间：
2019-01-24
影响因子：
6.2
通讯作者：
Elhampour, Ali
中科院分区：
文献类型：
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作者：
Fahimirad, Bahareh;Rajabi, Maryam;Elhampour, Ali
本工作采用一种新合成的纳米吸附剂对药物阿米替林(AMT)和去甲替林(NRT)进行快速、简便的萃取和浓缩，并用高效液相色谱对其进行测定。重点研究了新型高效吸附剂Fe3O4@SiO_2@N-3的简便合成，以及泡沫盐辅助分散磁微固相萃取法。采用的方法和用富氮基团对Fe3O4@SiO_2进行表面修饰，增加了所用纳米吸附剂与分析物之间的相互作用，提高了萃取率。FT-IR、FE-SEM、XRD和VSM分析技术证实了所合成的纳米吸附剂的准确性。为了获得最佳的实验条件，采用中心复合设计法对主要变量进行了优化。在最佳实验条件下，NRT和AMT的检出限、线性动态范围(LDRs)和相对标准偏差(RSD)分别为0.03和0.05 ng/m L，NRT和AMT的RSD分别为2.04和1.1，LDRs为0.07-2000 ng/mL。实验结果表明，该纳米吸附剂可重复使用5次，对AMT和NRT的萃取率分别大于80%和70%。(C)2018爱思唯尔B.V.保留所有权利。
In this work, a rapid and simple method is applied using a newly synthesized nanoadsorbent for the extraction and preconcentration of the drugs Amitriptyline (AMT) and Nortriptyline (NRT), which are then determined using high performance liquid chromatography. We focus on the facile synthesis of Fe3O4@SiO2@N-3, as a new and effective adsorbent, and the effervescent salt-assisted dispersive magnetic micro solid-phase extraction method. The applied method and modification of the surface of Fe3O4@SiO2 with the nitrogen-rich group lead to an increase in the interaction between the nanoadsorbent used and the analytes, and increase the extraction recovery. The accuracy of the synthesized nanoadsorbent is confirmed by the FT-IR, FE-SEM, XRD, and VSM analytical techniques. In order to obtain the best experimental conditions, optimization of the main variables involved is carried out using the central composite design method. Under the optimum experimental conditions, the limits of detection (LODs), linear dynamic ranges (LDRs), and relative standard deviations (RSDs for n = 5) for NRT and AMT were found to be as follow: LODs, 0.03 and 0.05 ng/mL; RSDs, 2.04 and 1.1 for NRT and AMT, respectively; and LDRs, 0.07-2000 ng/mL. Furthermore, the results obtained show that the nanoadsorbent can be used for five times with an extraction recovery more than 80% and 70% for AMT and NRT, respectively. (c) 2018 Elsevier B.V. All rights reserved.