Geographical Distribution and Surveillance of Crimean-Congo Hemorrhagic Fever in Iran
Geographical Distribution and Surveillance of Crimean-Congo Hemorrhagic Fever in Iran
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DOI：
10.1089/vbz.2009.0247
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发表时间：
2010-10-01
影响因子：
2.1
通讯作者：
Bouloy, Michele
中科院分区：
文献类型：
--
作者：
Chinikar, Sadegh;Ghiasi, Seyed Mojtaba;Bouloy, Michele
克里米亚-刚果出血热（Crimean-Congo hemorrhagic fever，CCHF）是由布尼亚病毒科、内罗病毒属CCHF病毒引起的病毒性出血热。该病毒通过接触受感染牲畜的血液和组织、蜱叮咬或接触受感染者传播给人类。自2000年以来，我们已经表明，伊朗30个省中有23个省流行这种疾病。其中，锡斯坦-瓦-俾路支斯坦、伊斯法罕、法尔斯、德黑兰、呼罗珊和胡泽斯坦的感染率分别最高。值得注意的是，伊朗东南部的锡斯坦-瓦-俾路支斯坦省的CCHF患病率最高，至少自2000年以来一直存在。对从伊朗患者中分离的CCHF病毒基因组的系统发育研究表明，与CCHF Matin株（巴基斯坦）有密切关系。我们在过去十年中的流行病学数据表明，在伊朗的不同省份，这种疾病的严重程度和死亡率相差很大。因此，更多的发病机制和系统发育的研究，应调查，以澄清这些差异。
Crimean-Congo hemorrhagic fever (CCHF) is viral hemorrhagic fever caused by CCHF virus, which belongs to the family Bunyaviridae and the genus Nairovirus. The virus is transmitted to humans via contact with blood and tissue from infected livestock, a tick bite, or contact with an infected person. Since 2000, we have shown the disease to be prevalent in 23 out of 30 provinces of Iran. Among those, Sistan-va-Baluchistan, Isfahan, Fars, Tehran, Khorasan, and Khuzestan demonstrated the highest infection, respectively. Notably, Sistan-va-Baluchistan province, southeast of Iran, has the highest prevalence of CCHF, and has shown to be present since at least 2000. Phylogenetic study of the CCHF virus genome isolated from Iranian patients showed a close relationship with the CCHF Matin strain (Pakistan). Our epidemiological data in the last decade have implied that the severity and fatality rate of the disease has ranged variably in different provinces of Iran. More pathogenesis and phylogenetic studies should therefore be investigated to clarify these differences.