Novel biodegradable hydrogels based on pachyman and its derivatives for drug delivery
Novel biodegradable hydrogels based on pachyman and its derivatives for drug delivery
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DOI：
10.1016/j.ijpharm.2008.12.023
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发表时间：
2009-04-17
影响因子：
5.8
通讯作者：
Hu, Xianming
中科院分区：
文献类型：
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作者：
Hu, Yan;Zhou, Xiaoju;Hu, Xianming
通过与双官能交联剂环氧氯丙烷（ECH）的交联反应，以茯苓多糖及其羟乙基衍生物（羟乙基茯苓多糖，HEP）为基础合成了两种水凝胶。通过改变交联剂和聚合物的含量，获得了具有不同交联比例的水凝胶。对水凝胶的结构和形态进行了表征，并且证实水凝胶的pH依赖性溶胀受聚合物性质、结构以及交联剂含量的强烈影响。在溶胀试验中，基于茯苓多糖的水凝胶表现出显著的pH敏感性，而基于羟乙基茯苓多糖的水凝胶往往具有显著的溶胀能力。在药物释放研究中，选择了两种药物水杨酸和牛血清白蛋白（BSA）作为模型药物。结果表明，两种水凝胶对蛋白质药物BSA的药物缓释性能均优于水杨酸。此外，通过两个模型方程评估，两种水凝胶中的药物传输机制均表现异常。重要的是，这项研究为基于这种天然多糖开发水凝胶提供了一个全新的视角，其作为一种新型蛋白质药物缓释载体具有巨大潜力。（C）2008 Elsevier B.V.保留所有权利。
Two kinds of hydrogels were synthesized based on pachyman and its hydroxyethyl derivatives (hydroxyethyl pachyman, HEP) by the crosslinking reactions with confunctional crosslinker agent epichlorohydrin (ECH). Hydrogels with different crosslinking ratio were obtained by varying the content of the crosslinker and the polymer. The structure and morphology of hydrogels were characterized and the pH-dependent swelling of hydrogels was confirmed to be strongly influenced by the polymer properties, structure and the crosslinker contents. In the swelling assays, the hydrogels based on pachyman exhibited significant pH sensitivity, while the hydrogels based on hydroxyethyl pachyman tended to have notable swelling capability. In the drug release study, two drugs salicylic acid and bovine serum albumin (BSA) were chosen as model drugs. The results indicated that both two kinds of hydrogels showed better drug sustained release behavior for protein drug BSA than salicylic acid. In addition, evaluated by two model equations, the drug transport mechanism showed anomalous in both two kinds of hydrogels. Importantly, this study offers an entirely new window of developing hydrogels based on this natural polysaccharide, which has great potential for using as a novel sustained release carrier for protein drugs. (C) 2008 Elsevier B.V. All rights reserved.