Dose effect relationship for epilation and late effects on spinal cord in rats exposed to gamma rays.
Dose effect relationship for epilation and late effects on spinal cord in rats exposed to gamma rays.
复制标题
暴露于伽马射线的大鼠脱毛的剂量效应关系和对脊髓的后期影响。
作者：
K. Masuda;B. Reid;H. Withers
大鼠脊髓（T7-T12）对单次和多次γ射线照射的反应显示，间隔24小时给予2次和间隔15天给予2次的阈值剂量之间无显著差异。脊髓损伤的潜伏期约为190天，此时瘫痪的发生率很高;在瘫痪概率较低的动物中，潜伏期小于190天。剂量分次有明显的节约效应：Strandqvist型等效应曲线的初始部分的斜率为0.44，导致50%动物瘫痪的剂量为0.36，“阈值”剂量为0.36。脱毛水平对预测脊髓损伤无明显意义。
The response of rat spinal cords (T7-T12) exposed to single and multifractionated gamma-ray exposures revealed no significant differences between the threshold doses for 2 fractions given with a 24-hr. interval and 2 fractions given with a 15-day interval. The latent period for spinal cord damage was about 190 days when the incidence of paralysis was high; it was less than this in animals with a lower probability of paralysis. There was a marked sparing effect from dose fractionation: the initial part of a Strandqvist type of isoeffect curve had a slope of 0.44 for doses causing paralysis in 50% of the animals, and 0.36 for "threshold" doses. The level of epilation was not useful for predicting spinal cord damage.