Utility of intraoperative frozen section analysis of sentinel lymph nodes in breast cancer
Utility of intraoperative frozen section analysis of sentinel lymph nodes in breast cancer
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DOI：
10.1016/s0002-9610(01)00794-2
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发表时间：
2001-12-01
影响因子：
3
通讯作者：
McMasters, KM
中科院分区：
文献类型：
--
作者：
Chao, C;Wong, SL;McMasters, KM
背景：术中前哨淋巴结（SLN）冰冻切片病理分析可以指导淋巴结转移患者立即（单期）完成腋窝清扫。方法：回顾性分析1998年1月至2000年9月连续203例行SLN活检患者术中病理会诊的结果。通过标准冷冻切片程序分析SLN。最后的病理分析采用苏木精和伊红（H&E）染色，每隔2mm对连续切片进行染色。结果：203例患者中，冷冻切片分析正确识别阳性或阴性结果185例（总准确率91%）。在53例sln中，17例冷冻切片为肿瘤阴性，而永久切片分析为阳性（敏感性68%）。真阳性和假阴性患者淋巴结转移的平均大小分别为6.2 mm和1.5 mm （P < 0.003）。报告1例假阳性SLN。结论：三分之二的患者无需再行腋窝淋巴结切除术。(C) 2002年医药股份有限公司版权所有。
Background: Intraoperative frozen section pathologic analysis of sentinel lymph node (SLN) may guide immediate (single-stage) completion axillary dissection for patients with nodal metastases.Methods: The results of 203 consecutive patients undergoing SLN biopsy who had intraoperative pathology consultation between January 1998 and September 2000 were reviewed. SLN were analyzed by standard frozen section procedures. Final pathologic analysis included hematoxylin and eosin (H&E) staining of serial sections at 2-mm intervals.Results: Frozen section analysis correctly identified a positive or negative result in 185 of 203 cases (overall accuracy 91%). In 17 of 53 cases, the SLNs were negative for tumor by frozen section, but positive on permanent section analysis (sensitivity 68%). The mean size of the nodal metastases was 6.2 mm and 1.5 mm in patients found to have true positive and false negative results, respectively (P < 0.003). A single false positive SLN is reported.Conclusions: Two thirds of the patients were spared the need for reoperative axillary lymphadenectomy. (C) 2002 Excerpta Medica, Inc. All rights reserved.