Presynaptic fibres of spiral neurons and reciprocal synapses in the organ of Corti in culture.
Presynaptic fibres of spiral neurons and reciprocal synapses in the organ of Corti in culture.
复制标题
培养的柯蒂氏器中螺旋神经元和交互突触的突触前纤维。
DOI：
10.1007/bf01218355
复制
发表时间：
1993
期刊：
影响因子：
--
通讯作者：
August,BK
中科院分区：
文献类型：
--
作者：
Sobkowicz,HM;Slapnick,SM;August,BK
Isolated segments of the newborn mouse organ of Corti were explanted together with the spiral ganglion components. Within the innervation provided by the spiral neurons, we observed presynaptic vesiculated nerve endings that form reciprocal ribbon-afferent/efferent synapses with inner hair cells. These intracochlear presynaptic fibres are characteristically located between adjoining inner hair cells, on the modiolar side, low and close to the supporting cells. The presynaptic fibres display different modes of synaptic connectivity, forming repetitive reciprocal synapses on single inner hair cells or on adjoining hair cells, or connecting adjoining inner hair cells through simultaneous efferent synapses. Many presynaptic fibres exhibit a distinctive ultrastructure: defined clusters of synaptic vesicles, dense core vesicles, coated vesicles, and mitochondria. These organelles occur focally at the synaptic sites; beyond the efferent synaptic specializations, the endings appear quite nondescript and afferent-like.We believe that the reciprocal synapses, although observed in cultures of the organ of Corti, represent real intracochlear synaptic arrangements providing a feedback mechanism between the primary sensory receptors and a special class of spiral ganglion cells that have yet to be recognized in the organin situ.
