Palladium(0)-Catalyzed Iminohalogenation of Alkenes: Synthesis of 2-Halomethyl Dihydropyrroles and Mechanistic Insights into the Alkyl Halide Bond Formation
Palladium(0)-Catalyzed Iminohalogenation of Alkenes: Synthesis of 2-Halomethyl Dihydropyrroles and Mechanistic Insights into the Alkyl Halide Bond Formation
复制标题
钯(0) 催化的烯烃亚氨基卤化：2-卤甲基二氢吡咯的合成以及烷基卤化物键形成的机理见解
DOI：
10.1002/anie.201410996
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发表时间：
2015-03-02
影响因子：
16.6
通讯作者：
Tong, Xiaofeng
中科院分区：
文献类型：
--
作者：
Chen, Chen;Hou, Longlei;Tong, Xiaofeng
尽管在碳卤化物还原消除方面已经取得了进展，但烷基溴和烷基氯类似物仍然是一个挑战。在这里，钯（0）催化的亚胺卤化，-不饱和肟酯的描述，和使用的贫电子膦配体被证明是至关重要的，以促进烷基溴和氯还原消除。此外，还建立了S（N）2型烷基溴和氯的还原消除反应。
Although the advances on carbon halide reductive elimination have been made, the alkyl bromide and chloride analogues remain a challenge. Here, a palladium(0)-catalyzed iminohalogenation of ,-unsaturated oxime esters is described, and the use of electron-poor phosphine ligands proved to be crucial to promoting alkyl bromide and chloride reductive elimination. Furthermore, S(N)2-type alkyl bromide and chloride reductive elimination has also been established.