Material-specific lateralization of memory encoding in the medial temporal lobe: Blocked versus event-related design
Material-specific lateralization of memory encoding in the medial temporal lobe: Blocked versus event-related design
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DOI：
10.1016/j.neuroimage.2005.04.033
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发表时间：
2005-08-01
期刊：
影响因子：
5.7
通讯作者：
Richardson, MP
中科院分区：
文献类型：
--
作者：
Powell, HWR;Koepp, MJ;Richardson, MP
损伤缺陷的研究提供了证据，左内侧颞叶（MTL）介导的言语记忆编码和右MTL介导的非言语记忆编码之间的功能分离。虽然少数功能性MRI研究已经证明了类似的发现，但没有一项研究专门使用随后的记忆效应来寻找材料特异性偏侧化。此外，在许多功能磁共振成像研究中，编码活动位于后部MTL结构，与病变缺陷和正电子发射断层扫描（PET）证据不一致。在这项研究中，我们使用了事件相关的功能磁共振成像记忆编码范式，以证明在内侧颞叶的10名健康对照组的编码材料特定的偏侧化。激活左侧的文字编码，双边的图片编码，和右侧的脸编码。其次，我们证明了使用事件相关分析显示的激活位置比使用相同数据的块分析显示的位置更靠前。这表明，前MTL结构的基础上的记忆编码，判断随后的记忆效果，和更多的后活动检测到在其他功能磁共振成像研究与缺陷的封闭设计的记忆编码的分析。(c)2005年爱思唯尔公司All rights reserved.
Lesion-deficit studies have provided evidence for a functional dissociation between the left medial temporal lobe (MTL) mediating verbal memory encoding and right MTL mediating non-verbal memory encoding. While a small number of functional MRI studies have demonstrated similar findings, none has looked specifically for material-specific lateralization using subsequent memory effects. In addition, in many fMRI studies, encoding activity has been located in posterior MTL structures, at odds with lesion-deficit and positron emission tomography (PET) evidence. In this study, we used an event-related fMRI memory encoding paradigm to demonstrate a material-specific lateralization of encoding in the medial temporal lobes of ten healthy control subjects. Activation was left-lateralized for word encoding, bilateral for picture encoding, and right-lateralized for face encoding. Secondly, we demonstrated the locations of activations revealed using an event-related analysis to be more anterior than those revealed using a blocked analysis of the same data. This suggests that anterior MTL structures underlie memory encoding as judged by subsequent memory effects, and that more posterior activity detected in other fMRI studies is related to deficiencies of blocked designs in the analysis of memory encoding. (c) 2005 Elsevier Inc. All rights reserved.