Nociceptin impairs acquisition of novel object recognition memory in perirhinal cortex
Nociceptin impairs acquisition of novel object recognition memory in perirhinal cortex
复制标题
伤害感受肽损害鼻周皮层新物体识别记忆的获取
DOI：
10.1016/j.nlm.2019.04.015
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发表时间：
2019-07-01
影响因子：
2.7
通讯作者：
Xin, Hong-bo
中科院分区：
文献类型：
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作者：
Han, Ren-wen;Tian, Ao-wen;Xin, Hong-bo
伤害感受肽/孤啡肽 FQ (N/OFQ) 在空间记忆、恐惧记忆和识别记忆的调节中发挥着重要作用。 N/OFQ 受体高度分布在鼻周皮层，这是参与调节新物体识别 (NOR) 记忆的关键大脑区域。然而，N/OFQ 在鼻周皮层 NOR 记忆中的作用仍不清楚。此外，N/OFQ 对 NOR 记忆不同阶段的影响仍不清楚。在 NOR 任务中，我们发现训练前脑室内（冰冷）注射 N/OFQ（0.3 和 1 nmol）会以剂量依赖性方式损害长期记忆。然而，训练后立即冰冷输注 N/OFQ 即使在 3 nmol 的高剂量下也不会影响 NOR 记忆巩固。测试前冰冷注射 N/OFQ (1 nmol) 也不影响 NOR 记忆检索。这些数据表明 N/OFQ 在采集阶段对长期 NOR 存储器进行负调制。此外，N/OFQ（1 nmol，冰冷）的遗忘作用可以通过选择性N/OFQ受体拮抗剂[Nphe（1）]N/OFQ（1-13）NH2（10 nmol，icv）预处理来拮抗，表明药理学特异性。然后，我们发现训练前将 N/OFQ（0.1 和 0.3 nmol/侧）输注到双侧鼻周皮层会损害长期 NOR 记忆，这表明鼻周皮层是介导 NOR 任务中 N/OFQ 遗忘效应的关键大脑结构。总之，我们的数据首次表明，鼻周皮质中的 N/OFQ 通过 NOP 受体损害 NOR 记忆获取。
Nociceptin/Orphanin FQ (N/OFQ) plays an important role in the regulation of spatial, fear and recognition memories. N/OFQ receptors are highly distributed in the perirhinal cortex, which is a key brain area involved in modulating novel object recognition (NOR) memory. However, the role of N/OFQ in NOR memory in the perirhinal cortex was still unknown. Moreover, the effects of N/OFQ on different stages of NOR memory were still unclear. In NOR task, we found that pre-training intracerebroventricular (icy) injection of N/OFQ (0.3 and 1 nmol) impaired long-term memory in a dose-dependent manner. However, icy infusion of N/OFQ immediately after training did not affect NOR memory consolidation even at a high dose of 3 nmol. Pre-test icy injection of N/OFQ (1 nmol) also did not influence NOR memory retrieval. These data indicate that N/OFQ negatively modulates long-term NOR memory during the acquisition phase. Furthermore, the amnesia effect of N/OFQ (1 nmol, icy) could be antagonist by pre-treatment with the selective N/OFQ receptor antagonist [Nphe(1)]N/OFQ(1-13) NH2 (10 nmol, icv), indicating pharmacological specificity. Then, we found that pre-training infusion of N/OFQ (0.1 and 0.3 nmol/side) into the bilateral perirhinal cortex impaired long-term NOR memory, suggesting the perirhinal cortex is a critical brain structure in mediating the amnesic effect of N/OFQ in NOR task. In conclusion, our data, for the first time, indicate that N/OFQ in the perirhinal cortex impairs NOR memory acquisition through the NOP receptors.