Characterisation of chicken viperin
Characterisation of chicken viperin
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DOI：
10.1016/j.molimm.2014.09.011
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发表时间：
2015-02-01
影响因子：
3.6
通讯作者：
Bean, Andrew G. D.
中科院分区：
文献类型：
--
作者：
Goossens, Kate E.;Karpala, Adam J.;Bean, Andrew G. D.
识别免疫途径，保护免受病原体可能会导致新的分子治疗牲畜和人类健康。干扰素（IFN）是一个主要的反应途径，刺激多个基因靶向减少病毒。蝰蛇蛋白是一种这样的干扰素刺激基因（ISG），有助于保护哺乳动物免受病毒的侵害，并可能以同样的方式保护鸡。在鸡中，ISG通常没有得到很好的表征，蝰蛇蛋白与其他ISG一起可能在保护免受病毒感染方面很重要。在这里，我们确定了鸡蝰蛇蛋白（ch-蝰蛇蛋白），并表明，ch-蝰蛇蛋白上调响应病毒的签名分子。我们进一步表明，蝰蛇蛋白上调响应病毒感染在体内。这些数据将有利于研究人员针对鸡的抗病毒途径。皇冠版权所有（C）2014由爱思唯尔有限公司出版。保留所有权利。
The identification of immune pathways that protect against pathogens may lead to novel molecular therapies for both livestock and human health. Interferon (IFN) is a major response pathway that stimulates multiple genes targeted towards reducing virus. Viperin is one such interferon stimulated gene (ISG) that helps protect mammals from virus and may be critical to protecting chickens in the same way. In chickens, ISGs are not generally well characterised and viperin, in concert with other ISGs, may be important in protecting against virus. Here we identify chicken viperin (ch-viperin) and show that ch-viperin is upregulated in response to viral signature molecules. We further show that viperin is upregulated in response to virus infection in vivo. This data will benefit investigators targeting the antiviral pathways in the chicken. Crown Copyright (C) 2014 Published by Elsevier Ltd. All rights reserved.