Functional expression of CXCR4 in S. cerevisiae: development of tools for mechanistic and pharmacologic studies.
Functional expression of CXCR4 in S. cerevisiae: development of tools for mechanistic and pharmacologic studies.
复制标题
CXCR4 在酿酒酵母中的功能表达：机制和药理学研究工具的开发。
DOI：
10.1007/978-3-662-05403-1_9
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Peiper,SC
中科院分区：
文献类型：
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作者：
Zhang,WB;Wang,ZX;Murray,JL;Fujii,N;Broach,J;Peiper,SC
趋化因子是对白细胞亚群的定向迁移进行编程的细胞因子（Loetscher et al. 2000）。这些小蛋白（~8-14 kDa）形成了最大的分泌型细胞间信使家族，目前已识别出超过43个成员。该家族的特征在于存在四个位置保守的半胱氨酸残基，并且基于两个氨基近端半胱氨酸的关系被细分为四个分支：C-C、C-X-C、C-X3-C和C。趋化因子的细胞信号由G蛋白偶联受体（GPCR）家族的成员转导，所述GPCR家族也沿着这四个亚类共分离（沿着）（Murphy等，2000）。现在人们认识到，除了通过招募白细胞亚群来促进炎症外，趋化因子在引导血液淋巴系统以外的组织发育方面发挥着核心作用。
Chemokines are cytokines that program directed migration of leukocyte subsets (Loetscher et al. 2000). These small proteins (~8–14 kDa) form the largest family of secreted intercellular messengers, having over 43 members recognized at this time. The family is characterized by the presence of four positionally conserved cysteine residues and subdivided into four branches based on the relationship of the two amino-proximal cysteines: C-C, C-X-C, C-X3-C, and C. Cellular signals for chemokines are transduced by members of the G-protein coupled receptor (GPCR) family that also cosegregate along these four subdivisions (Murphy et al. 2000). It is now recognized that in addition to promoting inflammation through recruitment of leukocyte subsets, chemokines play a central role in directing the development of tissues outside the hemato-lymphoid system.