Bilateral LMAN lesions cancel differences in HVC neuronal recruitment induced by unilateral syringeal denervation. Lateral magnocellular nucleus of the anterior neostriatum.
Bilateral LMAN lesions cancel differences in HVC neuronal recruitment induced by unilateral syringeal denervation. Lateral magnocellular nucleus of the anterior neostriatum.
复制标题
双侧 LMAN 损伤消除了单侧注射器去神经支配引起的 HVC 神经元募集差异。
DOI：
10.1007/s00359-002-0355-1
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Nottebohm,F
中科院分区：
文献类型：
--
作者：
Wilbrecht,L;Petersen,T;Nottebohm,F
26日龄的雄性斑马雀接受(1)单侧气管脊髓环神经切断，(2)双侧新纹状体前外侧大细胞核(LMAN)损毁，(3)两种手术。所有的鸟都和一只成年鸟在一起，雄性鸟儿作为家教一直唱到65天。气管-注射器神经切断的鸟类能够模仿这个模型，但LMAN损伤的鸟类不能。细胞分裂的标志物溴脱氧尿嘧啶核苷在61-65天孵化后肌肉注射，所有禽类在91天龄时被杀。气管环切开侧高声中枢溴脱氧尿嘧啶核苷阳性神经元的数量是神经切断侧的两倍。当神经切断术结合双侧LMAN损毁时，这种不对称性消失。后一种操作本身对新神经元的数量没有影响。我们认为，单一的神经切断在学习中产生了半球不对称，反映在新的神经元重新聚集中，当LMAN病变阻止学习时，这种不对称消失了。
Twenty-six-day-old male zebra finches received (1) unilateral section of their tracheosyringeal nerve, (2) bilateral lesions of the lateral magnocellular nucleus of the anterior neostriatum (LMAN), and (3) both operations. All birds were kept with an adult, singing male as a tutor until day 65. Tracheo-syringeal nerve-cut birds were able to imitate this model, but LMAN-lesioned birds were not. Bromodeoxyuridine, a marker of cell division, was injected intramuscularly during post-hatching days 61–65 and all birds were killed at 91 days of age. The number of bromodeoxyuridine+ neurons in the high vocal center of the tracheosyringeal-cut birds was twice as high in the intact as in the nerve cut side. This asymmetry disappeared when nerve section was combined with bilateral LMAN lesions. The latter operation, by itself, had no effect on new neuron counts. We suggest that the single nerve cut produced a hemispheric asymmetry in learning, reflected in new neuron recruitment, which disappeared when LMAN lesions blocked learning.