Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle
Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle
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DOI：
10.1016/j.micinf.2014.10.001
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发表时间：
2014-10-01
影响因子：
5.8
通讯作者：
Bachrati, Csanad Z.
中科院分区：
文献类型：
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作者：
Palmai-Pallag, Timea;Bachrati, Csanad Z.
炎症是免疫系统对微生物、刺激物或损伤不断挑战的最终反应。炎症级联反应起始于模式识别受体（PRR）对微生物来源的病原体相关分子模式（PAMP）和宿主细胞来源的损伤相关分子模式（DAMP）的识别。DNA作为分子PAMP或DAMP被直接或通过特异性结合蛋白感知以引发促炎反应。这些DNA结合蛋白中的一些也参与典型的DNA修复途径，并识别受损的DNA以启动DNA损伤反应。在这篇综述中，我们的目标是通过代表性的例子捕捉DNA损伤反应和促炎信号之间复杂的相互作用的本质。(C)2014巴斯德研究所。出版社：Elsevier Masson SAS All rights reserved.
Inflammation is the ultimate response to the constant challenges of the immune system by microbes, irritants or injury. The inflammatory cascade initiates with the recognition of microorganism-derived pathogen associated molecular patterns (PAMPs) and host cell-derived damage associated molecular patterns (DAMPs) by the pattern recognition receptors (PRRs). DNA as a molecular PAMP or DAMP is sensed directly or via specific binding proteins to instigate pro-inflammatory response. Some of these DNA binding proteins also participate in canonical DNA repair pathways and recognise damaged DNA to initiate DNA damage response. In this review we aim to capture the essence of the complex interplay between DNA damage response and the pro-inflammatory signalling through representative examples. (C) 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.