Changes in Days of Unhealthy Alcohol Use and Antiretroviral Therapy Adherence, HIV RNA Levels, and Condomless Sex: A Secondary Analysis of Clinical Trial Data
Changes in Days of Unhealthy Alcohol Use and Antiretroviral Therapy Adherence, HIV RNA Levels, and Condomless Sex: A Secondary Analysis of Clinical Trial Data
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DOI：
10.1007/s10461-019-02742-y
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发表时间：
2020-06-01
影响因子：
4.4
通讯作者：
Silverberg, Michael J.
中科院分区：
文献类型：
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作者：
Satre, Derek D.;Sarovar, Varada;Silverberg, Michael J.
在参加酒精干预试验并随访12个月的HIV感染者（PWH）样本中，我们检查了天数变化（即，减少，增加，无变化[参考]），不健康饮酒（女性/男性饮用>= 4/>= 5杯饮料），抗逆转录病毒治疗依从性（>= 95%依从性），病毒抑制（HIV RNA < 75拷贝/mL），与HIV阴性/身份不明的伴侣无安全套性行为，双重风险结局（HIV RNA >= 75拷贝/mL+无安全套性行为）。样本包括566名完成基线、6个月和12个月评估的PWH（96.8%男性; 63.1%白色; 93.9% HIV RNA < 75拷贝/mL）。不健康饮酒天数的减少与病毒抑制可能性的增加相关（比值比[OR] 3.78; 95%置信区间[CI] 1.06，13.51，P = .04），而无变化。不健康饮酒天数的增加与无安全套性行为的可能性增加相关（OR 3.13; 95%CI 1.60，6.12，P < .001）。增加或减少均与依从性或双重风险结局无关。在连续量表上，前一个月不健康饮酒每增加1天，95%依从性的几率降低6%（OR 0.94，95%CI 0.88，1.00，P = 0.04）。
In a sample of people with HIV (PWH) enrolled in an alcohol intervention trial and followed for 12 months, we examined the association of changes in days (i.e., decrease, increase, no change [reference]) of unhealthy drinking (consuming >= 4/>= 5 drinks for women/men) with antiretroviral therapy adherence (>= 95% adherent), viral suppression (HIV RNA < 75 copies/mL), condomless sex with HIV-negative/unknown status partners, and dual-risk outcome (HIV RNA >= 75 copies/mL plus condomless sex). The sample included 566 PWH (96.8% male; 63.1% White; 93.9% HIV RNA < 75 copies/mL) who completed baseline, 6-, and 12-month assessments. Decrease in days of unhealthy drinking was associated with increased likelihood of viral suppression (odds ratio [OR] 3.78; 95% confidence interval [CI] 1.06, 13.51, P = .04) versus no change. Increase in days of unhealthy drinking was associated with increased likelihood of condomless sex (OR 3.13; 95% CI 1.60, 6.12, P < .001). Neither increase nor decrease were associated with adherence or dual-risk outcome. On a continuous scale, for each increase by 1 day of unhealthy drinking in the prior month, the odds of being 95% adherent decreased by 6% (OR 0.94, 95% CI 0.88, 1.00, P = 0.04).