Increased response to morphine in mice lacking protein kinase C epsilon
Increased response to morphine in mice lacking protein kinase C epsilon
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DOI：
10.1111/j.1601-183x.2006.00261.x
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发表时间：
2007-06-01
影响因子：
2.5
通讯作者：
Messing, R. O.
中科院分区：
文献类型：
--
作者：
Newton, P. M.;Kim, J. A.;Messing, R. O.
The protein kinase C (PKC) family of serine-threonine kinases has been implicated in behavioral responses to opiates, but little is known about the individual PKC isozymes involved. Here, we show that mice lacking PKC epsilon have increased sensitivity to the rewarding effects of morphine, revealed as the expression of place preference and intravenous self-administration at very low doses of morphine that do not evoke place preference or self-administration in wild-type mice. The PKC epsilon null mice also show prolonged maintenance of morphine place preference in response to repeated testing when compared with wild-type mice. The supraspinal analgesic effects of morphine are enhanced in PKC epsilon null mice, and the development of tolerance to the spinal analgesic effects of morphine is delayed. The density of mu-opioid receptors and their coupling to G-proteins are normal. These studies identify PKC epsilon as a key regulator of opiate sensitivity in mice.
