Neural interaction of the amygdala with the prefrontal and temporal cortices in the processing of facial expressions as revealed by fMRI
Neural interaction of the amygdala with the prefrontal and temporal cortices in the processing of facial expressions as revealed by fMRI
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DOI：
10.1162/089892901753294338
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发表时间：
2001-11-15
影响因子：
3.2
通讯作者：
Sadato, N
中科院分区：
文献类型：
--
作者：
Iidaka, T;Omori, M;Sadato, N
人类杏仁核在面部表情处理中的一些参与已经在神经成像研究中进行了研究，尽管对面部刺激的动机或情绪行为的神经机制尚未完全理解。我们调查，使用功能性磁共振成像（fMRI）和健康志愿者，杏仁核是如何与其他皮质区域的相互作用，而受试者正在判断面部的性别与消极的，积极的，或中性的情绪。通过减法分析数据，然后，为了阐明大脑内区域之间可能的相互作用，进行了几种分析（即，相关分析、心理生理交互作用分析和结构方程模型）。总的来说，在任务过程中观察到双侧梭状回、内侧颞叶、前额叶皮层和右顶叶的显著激活。减法结果表明，左杏仁核，右眶额皮质和颞叶皮质主要参与负性表达的加工。当正性条件减去负性条件时，右角回参与正性表达的加工。相关分析表明，左杏仁核的活动。在负减去中性减法条件下，与左前额叶皮层的活动呈正相关。心理生理交互作用显示，左杏仁核和右前额叶皮层的神经反应经历了条件特异性的变化之间的消极和积极的面孔条件。右侧杏仁核的活动也与右侧海马和颞中回的活动有交互作用。这些结果可能表明，左，右杏仁核在有效的面部表情加工中发挥了不同的作用，与其他皮层或皮层下区域的合作，与双边的前额叶皮层，右与右颞叶左侧。
Some involvement of the human amygdala in the processing of facial expressions has been investigated in neuroimaging studies, although the neural mechanisms underlying motivated or emotional behavior in response to facial stimuli are not yet fully understood. We investigated, using functional magnetic resonance imaging (fMRI) and healthy volunteers, how the amygdala interacts with other cortical regions while subjects are judging the sex of faces with negative, positive, or neutral emotion. The data were analyzed by a subtractive method, then, to clarify possible interaction among regions within the brain, several kinds of analysis (i.e., a correlation analysis, a psychophysiological interaction analysis and a structural equation modeling) were performed. Overall, significant activation was observed in the bilateral fusiform gyrus, medial temporal lobe, prefrontal cortex, and the right parietal lobe during the task. The results of subtraction between the conditions showed that the left amygdala, right orbitofrontal cortex, and temporal cortices were predominantly involved in the processing of the negative expressions. The right angular gyrus was involved in the processing of the positive expressions when the negative condition was subtracted from the positive condition. The correlation analysis showed that activity in the left amygdala. positively correlated with activity in the left prefrontal cortex under the negative minus neutral subtraction condition. The psychophysiological interaction revealed that the neural responses in the left amygdala and the right prefrontal cortex underwent the condition-specific changes between the negative and positive face conditions. The right amygdaloid activity also had an interactive effect with activity in the right hippocampus and middle temporal gyrus. These results may suggest that the left and right amygdalae play a differential role in effective processing of facial expressions in collaboration with other cortical or subcortical regions, with the left being related with the bilateral prefrontal cortex, and the right with the right temporal lobe.