Exercise training can modify the natural history of diabetic peripheral neuropathy
Exercise training can modify the natural history of diabetic peripheral neuropathy
复制标题
DOI：
10.1016/j.jdiacomp.2005.07.005
复制
发表时间：
2006-07-01
影响因子：
3
通讯作者：
Fallucca, Francesco
中科院分区：
文献类型：
--
作者：
Balducci, Stefano;Iacobellis, Gianluca;Fallucca, Francesco
背景：糖尿病是周围神经病变（DPN）的最重要原因。DPN的确切治疗方法尚未确定，关于运动训练对DPN作用的报道也很少。本研究的目的：我们试图检查长期运动训练对1型和2型糖尿病患者DPN发展的影响。参与者和方法：78例无周围DPN体征和症状的糖尿病患者被纳入研究，随机分为两组：31例糖尿病患者[15例女性，16例男性; 49 ± 15.5岁;体重指数（BMI）= 27.9 +/- 4.7]，在50%至85%的心率储备下，在跑步机上进行规定和监督下的每周4小时快走（运动组：EXE）和47名糖尿病参与者的对照组（CON; 24名女性，23名男性; 52.9 +/- 13.4岁; BMI=30.9 +/- 8.4）。测定振动觉阈值（VPT）、神经远端潜伏期（DL）、神经传导速度（NCV）和神经动作电位振幅（NAPA）。结果如下：在研究期间，我们发现EXE组和CON组的腓肠和腓肠运动神经的NCV的A（delta）差异显著（P
Background: Diabetes is the most important cause of peripheral neuropathy (DPN). No definitive treatment for DPN has been established, and very few data on the role of exercise training on DPN have been reported. Aim of the study: We sought to examine the effects of long-term exercise training on the development of DPN in both Types 1 and 2 diabetic patients. Participants and methods: Seventy-eight diabetic patients without signs and symptoms of peripheral DPN were enrolled, randomized, and subdivided in two groups: 31 diabetic participants [15 f, 16 m; 49 +/- 15.5 years old; body mass index (BMI)= 27.9 +/- 4.7], who performed a prescribed and supervised 4 h/week brisk walking on a treadmill at 50% to 85% of the heart rate reserve (exercise group: EXE), and a control group of 47 diabetic participants (CON; 24 f, 23 m; 52.9 +/- 13.4 years old; BMI=30.9 +/- 8.4). Vibration perception threshold (VPT), nerve distal latency (DL), nerve conduction velocity (NCV), and nerve action potential amplitude (NAPA) in the lower limbs were measured. Results: We found significant differences on A (delta) in NCV for both peroneal and sural motor nerve between the EXE and CON groups during the study period (P