PARASITE DEVELOPMENT AND HOST RESPONSES DURING THE ESTABLISHMENT OF TRYPANOSOMA-BRUCEI INFECTION TRANSMITTED BY TSETSE-FLY
PARASITE DEVELOPMENT AND HOST RESPONSES DURING THE ESTABLISHMENT OF TRYPANOSOMA-BRUCEI INFECTION TRANSMITTED BY TSETSE-FLY
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DOI：
10.1017/s0031182000054354
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发表时间：
1984-01-01
期刊：
影响因子：
2.4
通讯作者：
EMERY, DL
中科院分区：
文献类型：
--
作者：
BARRY, JD;EMERY, DL
接种T.在通过采采蝇将布鲁氏菌感染到大型哺乳动物中时，由于锥虫增殖而产生局部皮肤反应，即下疳。对山羊引流淋巴结的传入和传出淋巴管进行了插管，并检查了细胞反应的发生、寄生虫从下疳的迁移以及抗原变异和特异性免疫应答的发展。下疳在感染后第3天首次被检测到，在第6天达到高峰，然后消退。到第10天，淋巴细胞输出增加6至8倍，在此期间淋巴母细胞的数量增加了50倍。然后两人都拒绝了。在下疳发生前1-2天，在淋巴液中检测到锥虫，在5-6天达到高峰，在下疳发生过程中下降，然后再次达到高峰。在第4-5天出现血流群体，并显示出与淋巴中不同的动力学。寄生虫通过寄生虫循环。淋巴传播的锥虫种群高度多形性。淋巴中的寄生虫表达了采采蝇中特有的可变抗原类型（VAT）的混合物，随后是其他VAT的混合物。两组在外观上重叠。在血流中，同样的事件发生在2或3天后。通过放射免疫测定法和凝集法测定的特异性抗体应答在首次检测各VAT后几天内出现。活性首先出现在淋巴中，然后出现在血浆中。
Following inoculation of T. brucei into large mammals by the tsetse fly, a local skin reaction, the chancre, develops due to trypanosome proliferation. The afferent and efferent lymphatics of the draining lymph node in goats were cannulated and the onset of a cellular reaction, the emigration of the parasite from the chancre and the development of both antigenic variation and the specific immune response were examined. The chancre first became detectable by day 3 post-infection, peaked by day 6 and then subsided. Lymphocyte output increased 6- to 8-fold by day 10 and the number of lymphoblasts increased 50-fold in this period. Both then declined. Trypanosomes were detected in lymph 1-2 days before the chancre, peaked by days 5-6, declined during development of the chancre and then peaked again. The bloodstream population appeared by days 4-5 and displayed different kinetics from that in lymph. Recirculation of parasites through the lymphatics ensued. Lymph-borne trypanosome populations were highly pleomorphic. Parasites in lymph expressed a mixture of the variable antigen types (VAT) which are found characteristically in the tsetse fly, this being followed by a mixture of other VAT. The 2 groups overlapped in appearance. In the bloodstream the same sequence of events occurred although 2 or 3 days later. The specific antibody response, as measured by radioimmunoassay and agglutination, arose within a few days of the 1st detection of each VAT. Activities appeared 1st in the lymph and then in plasma.