Network motifs: Simple building blocks of complex networks
Network motifs: Simple building blocks of complex networks
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DOI：
10.1126/science.298.5594.824
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发表时间：
2002-10-25
期刊：
影响因子：
56.9
通讯作者：
Alon, U
中科院分区：
文献类型：
--
作者：
Milo, R;Shen-Orr, S;Alon, U
在许多科学领域都研究了复杂的网络。为了揭示其结构设计原理，我们定义了网络图案，即在复杂网络中发生的互连模式，数量明显高于随机网络中的数字。我们发现了来自生物化学，神经生物学，生态学和工程的网络中的这种图案。生态食品网共享的图案与大肠杆菌和酿酒酵母的遗传网络共享的图案不同，或者与在万维网中发现的图案。在执行信息处理的网络中发现了类似的基序，即使它们描述的元素与细胞内的生物分子和秀丽隐杆线虫中神经元之间的突触连接不同。因此，主题可以定义网络的通用类。这种方法可能会揭示大多数网络的基本构建块。
Complex networks are studied across many fields of science. To uncover their structural design principles, we defined network motifs, patterns of interconnections occurring in complex networks at numbers that are significantly higher than those in randomized networks. We found such motifs in networks from biochemistry, neurobiology, ecology, and engineering. The motifs shared by ecological food webs were distinct from the motifs shared by the genetic networks of Escherichia coli and Saccharomyces cerevisiae or from those found in the World Wide Web. Similar motifs were found in networks that perform information processing, even though they describe elements as different as biomolecules within a cell and synaptic connections between neurons in Caenorhabditis elegans. Motifs may thus define universal classes of networks. This approach may uncover the basic building blocks of most networks.