Crystalloid inclusions in brain macrophages and hemopoietic tissue in GFAP-IL3 mice resemble inclusions identified in multiple sclerosis.
Crystalloid inclusions in brain macrophages and hemopoietic tissue in GFAP-IL3 mice resemble inclusions identified in multiple sclerosis.
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GFAP-IL3 小鼠脑巨噬细胞和造血组织中的晶体内含物类似于多发性硬化症中发现的内含物。
DOI：
10.1080/019131299281437
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发表时间：
1999
影响因子：
1
通讯作者：
Campbell,IL
中科院分区：
文献类型：
--
作者：
Powell,HC;Garrett,RS;Muehlenbachs,A;Brett,FM;Campbell,IL
在人类脱髓鞘疾病的脑巨噬细胞中观察到的晶体状包涵体或“极体”是一个形态学之谜。在来自GFAP-IL 3小鼠的脑巨噬细胞中检测到类似的内含物，GFAP-IL 3小鼠是巨噬细胞介导的脱髓鞘的转基因鼠模型。小鼠还显示造血组织中的内含物。它们似乎分别与吞噬作用和分泌有关，这一事实证明，在吞噬细胞中，它们经常与溶体合并，并且受影响的细胞显示出向噬菌体开放的空通道。基于超微结构和免疫定位研究，使用伴侣蛋白-10，溶菌酶和组织蛋白酶的作者认为，这些夹杂物是一致的吞噬相关的分泌产物。这项研究可能提供洞察的性质和意义，最近发现的类似巨噬细胞夹杂物在多发性硬化症。
Crystalloid inclusions or "pole bodies" observed in brain macrophages in human demyelinating disease represent a morphological enigma. Similar inclusions were detected in brain macrophages from the GFAP-IL3 mouse, a transgenic murine model for macrophage mediated demyelination. Mice also showed inclusions in hematopoietic tissue. They appear to be related to phagocytosis and secretion, respectively, as evidenced by the fact that in phagocytosing cells they often merged with lysozomes and that affected cells showed empty channels open to the interstitium. Based on ultrastructural and immunolocalization studies using chaperonin-10, lysozyme, and cathepsin the authors suggest that these inclusions are consistent with phagocytosis-related secretory products. This study may provide insight into the nature and significance of similar macrophage inclusions recently identified in multiple sclerosis.