Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila
Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila
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DOI：
10.1016/s0092-8674(00)00040-4
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发表时间：
2000-08-04
期刊：
影响因子：
64.5
通讯作者：
Bellen, HJ
中科院分区：
文献类型：
--
作者：
Nolo, R;Abbott, LA;Bellen, HJ
无感觉(SENS)基因是果蝇胚胎和成体周围神经系统(PNS)大多数细胞类型正常发育所必需的。SENS是一种具有四个锌指的核蛋白，它在感觉器官前体(SOP)中表达，并且是正常神经基因表达所必需的。Sens在许多外胚层细胞中的异位表达导致PNS外部感觉器官的形成，并能够重建异位的神经场。因此，SENS对于PNS的发展既是必要的，也是充分的。我们的数据表明，原神经基因激活了SENS的表达。然后，SENS被要求进一步激活和维持原神经基因的表达。这种反馈机制对于选择性增强和维持SOP中原神经基因的表达是必不可少的。
The senseless (sens) gene is required for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS) of Drosophila. Sens is a nuclear protein with four Zn fingers that is expressed and required in the sensory organ precursors (SOP) for proper proneural gene expression. Ectopic expression of Sens in many ectodermal cells causes induction of PNS external sensory organ formation and is able to recreate an ectopic proneural field. Hence, sens is both necessary and sufficient for PNS development. Our data indicate that proneural genes activate sens expression. Sens is then in turn required to further activate and maintain proneural gene expression. This feedback mechanism is essential for selective enhancement and maintenance of proneural gene expression in the SOPs.