Circadian change of serum concentration of small dense LDL-cholesterol in type 2 diabetic patients
Circadian change of serum concentration of small dense LDL-cholesterol in type 2 diabetic patients
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DOI：
10.1016/j.cca.2009.11.017
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发表时间：
2010-02-02
影响因子：
5
通讯作者：
Miida, Takashi
中科院分区：
文献类型：
--
作者：
Hirayama, Satoshi;Soda, Satoshi;Miida, Takashi
背景：2型糖尿病患者发生动脉粥样硬化的风险高于非糖尿病患者。这种差异可能是由于糖尿病患者中小而密的低密度脂蛋白胆固醇（sLDL-C）水平升高所致。由于sLDL-C浓度升高高血脂症，这是夸大postprandially，我们研究是否sLDL-C水平增加postprandially在2型diabetes.Methods：我们获得了7个血液样本（30分钟前和2小时后，每餐，午夜）从15例糖尿病患者和10名正常对照。结果：糖尿病患者空腹sLDL-C浓度比对照组高60.3%（1.01 ± 0.21对0.63 ± 0.21 mmol/l，P < 0.01），空腹sLDL-C浓度比对照组高1.01 ± 0.21 mmol/l（P < 0.01），空腹sLDL-C浓度比对照组高1.01 ± 0.21 mmol/l（P < 0.01），空腹sLDL-C浓度比对照组高1.01 ± 0.21 mmol/l（P < 0.01），空腹sLDL-C浓度比对照组高1.01 ± 0.21 mmol/l（P < 0.01）。
Background: Type 2 diabetic patients have a higher risk of atherosclerosis than non-diabetic subjects. This difference may be attributable to increased levels of small dense low-density lipoprotein-cholesterol (sLDL-C) in diabetic patients. As the sLDL-C concentration is elevated in hypertriglyceridemia, which is exaggerated postprandially, we examined whether the sLDL-C level increases postprandially in type 2 diabetes.Methods: We obtained 7 blood samples (30 min before and 2 h after each meal, and at midnight) from 15 patients with diabetes and ten normal controls. Following the precipitation of very low-density lipoprotein and large buoyant LDL (bLDL) with heparin-Mg2+, the sLDL-C concentration was determined as the cholesterol concentration by a homogeneous assay.Results: The fasting sLDL-C concentration was 60.3% higher in the diabetic patients than in the controls (1.01 +/- 0.21 vs. 0.63 +/- 0.21 mmol/l,p