Massive hepatosplenomegaly caused by Penicillium marneffei associated with human immunodeficiency virus infection in a Thai patient.
Massive hepatosplenomegaly caused by Penicillium marneffei associated with human immunodeficiency virus infection in a Thai patient.
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一名泰国患者因人类免疫缺陷病毒感染而导致马尔尼菲青霉菌引起的大规模肝脾肿大。
DOI：
10.1136/jcp.55.2.143
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发表时间：
2002
影响因子：
3.4
通讯作者：
M. Plummeridge
中科院分区：
文献类型：
--
作者：
A C Bateman;G R Jones;S. O'Connell;F J Clark;M. Plummeridge
一名 29 岁泰国女性出现非特异性特征，检查显示左上区实变和肝脾肿大。最初的临床鉴别诊断包括结核病和类鼻疽。她入院四天后死亡，当时仍在接受调查。尸检显示人类免疫缺陷病毒抗体、播散性马尔尼菲青霉菌感染和肠炎沙门氏菌感染。马尔尼菲青霉是一种在东南亚被广泛描述的艾滋病病原体，但在英国却非常罕见。适当的抗真菌治疗可能与成功的结果相关。提高对这种临床关联的认识可能有助于对在英国就诊的东南亚受影响患者进行正确诊断。
A 29 year old Thai woman presented with non-specific features and examination revealed left upper zone consolidation and hepatosplenomegaly. The initial clinical differential diagnosis included tuberculosis and melioidosis. She died four days after admission, while still under investigation. Postmortem examination revealed antibodies to human immunodeficiency virus, disseminated Penicillium marneffei infection, and Salmonella enteritidis infection. Penicillium marneffei is a well described AIDS defining pathogen in South East Asia but is very rare in the UK. Appropriate antifungal treatment may be associated with a successful outcome. Increased awareness of this clinical association may enable correct diagnosis in affected patients from South East Asia presenting within the UK.