Integrin α10β1: A Collagen Receptor Critical in Skeletal Development
Integrin α10β1: A Collagen Receptor Critical in Skeletal Development
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DOI：
10.1007/978-94-017-9153-3_4
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发表时间：
2014-01-01
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影响因子：
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通讯作者：
Aszodi, Attila
中科院分区：
文献类型：
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作者：
Lundgren-Akerlund, Evy;Aszodi, Attila
整联蛋白α 10 β 1是软骨组织中最丰富的胶原结合整联蛋白，其表达模式与其他胶原结合整联蛋白的表达模式不同。体外和体内研究已经确定整合素α 10 β 1是软骨细胞分化的独特表型标志物，也是适当软骨发育所需的细胞-基质相互作用的关键介质。本章描述了整合素亚基α 10的结构，整合素10 β 1的组织分布，并更新了有关其调节和配体结合的可用信息。我们还总结了目前的信息α 10 β 1在间充质干细胞的软骨形成和骨骼生长中的功能作用。
Integrin alpha 10 beta 1 is the most abundant collagen-binding integrin in cartilaginous tissues and its expression pattern is distinct from that of other collagen-binding integrins. In vitro and in vivo studies have identified integrin alpha 10 beta 1 as a unique phenotypic marker for chondrocyte differentiation and a crucial mediator of cell-matrix interactions required for proper cartilage development. This chapter describes the structure of the integrin subunit alpha 10, the tissue distribution of the integrin 10 beta 1 and updates available information regarding its regulation and ligand binding. We also summarize current information on the functional roles of alpha 10 beta 1 in chondrogenesis of mesenchymal stem cells and in skeletal growth.