Bubble Motion in a Blood Vessel: Shear Stress Induced Endothelial Cell Injury
Bubble Motion in a Blood Vessel: Shear Stress Induced Endothelial Cell Injury
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DOI：
10.1115/1.3153310
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发表时间：
2009-07-01
影响因子：
1.7
通讯作者：
Eckmann, D. M.
中科院分区：
文献类型：
--
作者：
Mukundakrishnan, K.;Ayyaswamy, P. S.;Eckmann, D. M.
动脉气体栓塞对内皮细胞损伤的机制已被研究。这种机制涉及多个尺度。我们已经数值研究了宏观尺度的流动动力学，由于一个几乎闭塞的有限大小的气泡在各种尺寸的血管中的运动。由于血液的剪切稀化流变学和Fahraeus-Lindqvist效应两者的非牛顿行为已经被考虑。闭塞气泡动力学适合于轴对称处理。数值解揭示了气泡附近的一些流体动力学特征。大的时间和空间剪应力梯度发生在EC表面上。应力变化表现为行波的形式。梯度伴随着快速的符号变化。这些特征归因于在气泡附近的再循环区域（涡环）的发展。剪切应力梯度与符号反转一起可能部分地作为破坏内皮细胞膜完整性和功能性的潜在原因。[DOI：10.1115/1.3153310]
Mechanisms governing endothelial cell (EC) injury during arterial gas embolism have been investigated. Such mechanisms involve multiple scales. We have numerically investigated the macroscale flow dynamics due to the motion of a nearly occluding finite-sized air bubble in blood vessels of various sizes. Non-Newtonian behavior due to both the shear-thinning rheology of the blood and the Fahraeus-Lindqvist effect has been considered. The occluding bubble dynamics lends itself for an axisymmetric treatment. The numerical solutions have revealed several hydrodynamic features in the vicinity of the bubble. Large temporal and spatial shear stress gradients occur on the EC surface. The stress variations manifest in the form of a traveling wave. The gradients are accompanied by rapid sign changes. These features are ascribable to the development of a region of recirculation (vortex ring) in the proximity of the bubble. The shear stress gradients together with sign reversals may partially act as potential causes in the disruption of endothelial cell membrane integrity and functionality. [DOI: 10.1115/1.3153310]