Falls in older adults with multiple myeloma.
Falls in older adults with multiple myeloma.
复制标题
患有多发性骨髓瘤的老年人跌倒。
DOI：
10.1111/ejh.13009
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发表时间：
2018
影响因子：
3.1
通讯作者：
Fiala,MarkA
中科院分区：
文献类型：
--
作者：
Wildes,TanyaM;Fiala,MarkA
目的 检查患有多发性骨髓瘤的老年人跌倒的发生率、与跌倒相关的因素以及跌倒与生存之间的关系。方法在对监测、流行病学和最终结果 (SEER)-医疗保健健康结果调查 (MHOS) 链接数据库的分析中，我们检查了 405 名患有多发性骨髓瘤 (MM) 的老年人和 513 名匹配的非癌症对照者。主要结局是在过去 12 个月内自我报告的。 MHOS 中自我报告了年龄、种族、性别、症状和合并症。根据 SEER 数据计算生存率。结果 在 MM 患者中，171 名患者在诊断后 1 年内（第 1 组），234 名患者在诊断后 1 年以上（第 2 组）。第 1 组和第 2 组患者比对照组患者更有可能跌倒（26% 和 33% vs 23%，P=0.012）。在多变量分析中，在骨髓瘤患者（队列 1 和队列 2 合并）中，与跌倒相关的因素包括自我报告的疲劳（aOR 2.52 [95% CI 1.34-4.93]）、抑郁（aOR 1.90 [95% CI 1.14-3.18]）或总体健康状况较差（aOR 1.86 [95% CI 1.34-3.18]）。 1.05-3.36]）。跌倒与生存无关。结论 患有 MM 的老年人比匹配的对照组有更高的跌倒发生率。自我报告的疲劳、抑郁和较差的总体健康状况与跌倒的可能性更大有关。
ObjectiveTo examine the prevalence of falls, factors associated with falls and the relationship between falls and survival in older adults with multiple myeloma.MethodsIn an analysis of the Surveillance, Epidemiology and End Results (SEER)‐Medicare Health Outcomes Survey (MHOS)‐linked database, we examined 405 older adults with multiple myeloma (MM) and 513 matched non‐cancer controls. The primary outcome was self‐reported within the past 12 months. Age, race, gender, symptoms, and comorbidities were self‐reported in the MHOS. Survival was calculated from SEER data.ResultsOf the patients with MM, 171 were within 1 year of diagnosis (cohort 1) and 234 were ≥1 year postdiagnosis (cohort 2). Patients in cohorts 1 and 2 were more likely to have fallen than controls (26% and 33% vs 23%,P= .012). On multivariate analysis, among patients with myeloma (combined cohorts 1 and 2), factors associated with falls included self‐report of fatigue (aOR 2.52 [95% CI 1.34‐4.93]), depression (aOR 1.90 [95% CI 1.14‐3.18]), or poorer general health (aOR 1.86 [95% CI 1.05‐3.36]). Falls were not associated with survival.ConclusionsOlder adults with MM have a greater prevalence of falls than matched controls. Self‐reported fatigue, depression, and poorer general health are associated with greater odds of falls.