The Response of Macrophages and Neutrophils to Hypoxia in the Context of Cancer and Other Inflammatory Diseases.
The Response of Macrophages and Neutrophils to Hypoxia in the Context of Cancer and Other Inflammatory Diseases.
复制标题
在癌症和其他炎症性疾病的情况下，巨噬细胞和中性粒细胞对缺氧的反应。
DOI：
10.1155/2016/2053646
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发表时间：
2016
影响因子：
4.6
通讯作者：
Cramer T
中科院分区：
文献类型：
--
作者：
Egners A;Erdem M;Cramer T
缺氧(缺氧)是许多急慢性疾病的一个特征，对器官的恢复和恢复既有好处，也有坏处。在炎症的背景下，缺氧尤其重要，可以显著影响炎症性疾病的进程。巨噬细胞和中性粒细胞是天然免疫的主要细胞成分，当暴露在低氧条件下时，会显示出不同的特性。事实上，巨噬细胞和中性粒细胞功能的每一个方面都受到缺氧的影响，其中包括形态、迁移、趋化、与内皮细胞的黏附、细菌杀灭、分化/极化和促肿瘤活性。巨噬细胞和中性粒细胞功能的突出区域，如急性/慢性炎症和实体瘤的微环境，具有低氧水平的特点，表明低氧反应对这些细胞的正常功能至关重要。低氧诱导转录因子(HIF)家族成员是巨噬细胞和中性粒细胞的关键分子调节因子。在这篇综述中，我们将总结在癌症和其他慢性炎症性疾病的背景下巨噬细胞和中性粒细胞对低氧的分子反应，并讨论由此产生的潜在的治疗干预途径。
Lack of oxygen (hypoxia) is a hallmark of a multitude of acute and chronic diseases and can be either beneficial or detrimental for organ restitution and recovery. In the context of inflammation, hypoxia is particularly important and can significantly influence the course of inflammatory diseases. Macrophages and neutrophils, the chief cellular components of innate immunity, display distinct properties when exposed to hypoxic conditions. Virtually every aspect of macrophage and neutrophil function is affected by hypoxia, amongst others, morphology, migration, chemotaxis, adherence to endothelial cells, bacterial killing, differentiation/polarization, and protumorigenic activity. Prominent arenas of macrophage and neutrophil function, for example, acute/chronic inflammation and the microenvironment of solid tumors, are characterized by low oxygen levels, demonstrating the paramount importance of the hypoxic response for proper function of these cells. Members of the hypoxia-inducible transcription factor (HIF) family emerged as pivotal molecular regulators of macrophages and neutrophils. In this review, we will summarize the molecular responses of macrophages and neutrophils to hypoxia in the context of cancer and other chronic inflammatory diseases and discuss the potential avenues for therapeutic intervention that arise from this knowledge.