The Hedgehog and Wnt signaling pathways in cancer
The Hedgehog and Wnt signaling pathways in cancer
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DOI：
10.1038/35077219
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发表时间：
2001-05-17
期刊：
影响因子：
64.8
通讯作者：
Beachy, PA
中科院分区：
文献类型：
--
作者：
Taipale, J;Beachy, PA
Wnt和hedgehog（Hh）信号通路长期以来一直被认为在胚胎发育期间指导生长和模式化。最近的证据也暗示这些途径在胚胎后调节上皮细胞的干细胞数量，如皮肤和肠，不断更新。Wnt和Hh途径的病理作用已经从显示与组成性激活这些途径的转录应答的突变相关的特定人类癌症的高频率的研究中出现。这篇文章的重点是Hh和Wnt信号转导和审查的证据表明，与通路激活相关的肿瘤可能会导致错误的规范对干细胞或干细胞样的命运的细胞。
The Wnt and hedgehog (Hh) signalling pathways have long been known to direct growth and patterning during embryonic development. Recent evidence also implicates these pathways in the postembryonic regulation of stem-cell number in epithelia such as those of the skin and intestine, which undergo constant renewal. A pathological role for the Wnt and Hh pathways has emerged from studies showing a high frequency of specific human cancers associated with mutations that constitutively activate the transcriptional response of these pathways. This article focuses on Hh and Wnt signal transduction and reviews evidence suggesting that tumorigenesis associated with pathway activation may result from mis-specification of cells towards stem-cell or stem cell-like fates.