Nuclear protein 1 imparts oncogenic potential and chemotherapeutic resistance in cancer.
Nuclear protein 1 imparts oncogenic potential and chemotherapeutic resistance in cancer.
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DOI：
10.1016/j.canlet.2020.08.019
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发表时间：
2020-12-01
期刊：
影响因子：
9.7
通讯作者：
Costa M
中科院分区：
文献类型：
--
作者：
Murphy A;Costa M
核蛋白1（NUPR 1）也称为p8和转移候选物1（COM1），其作为转录调节因子发挥作用，并且在响应于各种细胞应激物的细胞周期、DNA损伤反应、凋亡、自噬和染色质重塑中起作用。自1999年首次提出它有助于癌症的发展和进展以来，许多研究试图揭示其功能。然而，NUPR1及其在癌症中的生物学相关性已被证明难以确定。基于NUPR 1在癌症中表达的证据，其功能从致癌和肿瘤发生延伸到转移和化疗抗性。NUPR 1的肿瘤抑制功能也已在多种癌症中被证实。总的来说，涉及NUPR 1和癌症的文献仅限于胰腺癌和乳腺癌，但在肺癌、结肠直肠癌、血液癌和前列腺癌等中NUPR 1的表达及其功能方面已经取得了重大进展。最近的证据有力地支持了这样的观点，即NUPR 1在化疗抗性中是关键的，当用抗癌化合物挑战时，NUPR 1通过介导抗凋亡活性和自噬两者。因此，了解NUPR 1指导的广泛分子功能具有重要意义。在这篇综述中，NUPR1的表达及其在乳腺癌，肺癌和结直肠癌的发展和进展中的作用将得到解决。
Nuclear protein 1 (NUPR1) also known as p8 and candidate of metastasis 1 (COM1) functions as a transcriptional regulator, and plays a role in cell cycle, DNA damage response, apoptosis, autophagy, and chromatin remodeling in response to various cellular stressors. Since it was first suggested to contribute to cancer development and progression in 1999, a number of studies have sought to reveal its function. However, NUPR1 and its biological relevance in cancer has proven difficult to pinpoint. Based on evidence of NUPR1 expression in cancer, its function extends from carcinogenesis and tumorigenesis to metastasis and chemotherapeutic resistance. A tumor suppressive function of NUPR1 has also been documented in multiple cancers. By and large, literature involving NUPR1 and cancer is confined to pancreatic and breast cancers, yet significant progress has been made with respect to NUPR1 expression and its function in lung, colorectal, blood, and prostate cancers, among others. Recent evidence strongly supports the notion that NUPR1 is key in chemotherapeutic resistance by mediating both anti-apoptotic activity and autophagy when challenged with anti-cancer compounds. Therefore, it is of significant importance to understand the broad range of molecular functions directed by NUPR1. In this review, NUPR1 expression and its role in breast, lung, and colorectal cancer development and progression will be addressed.
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