Effects of simulated high altitude on event-related potential (P300) and auditory brain-stem responses
Effects of simulated high altitude on event-related potential (P300) and auditory brain-stem responses
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DOI：
10.1016/j.clinph.2005.02.020
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发表时间：
2005-06-01
影响因子：
4.7
通讯作者：
Kobayashi, T
中科院分区：
文献类型：
--
作者：
Hayashi, R;Matsuzawa, Y;Kobayashi, T
目的：探讨低氧对认知功能的影响。方法：记录了7名男性受试者从海拔610英寸快速上升到模拟海拔4500米时的听觉脑干反应（ABR）和听觉诱发事件相关电位（ERP）。评估ABR和ERP各分量的振幅和潜伏期。结果：与610 m时相比，4500 m时ABR的I波和V波潜伏期均显著增加，I-V峰间潜伏期无变化；波I的振幅减小，波v的振幅没有变化，海拔的升高对N100的振幅和潜伏期没有影响。在低压-缺氧条件下暴露2小时后，P300潜伏期明显延长，但振幅无显著变化。在4500 m时，吸入氧气后P300潜伏期恢复到基线值。结论：我们的研究结果表明，在低气压和低气压条件下，即使听觉刺激强度降低，也可能通过提供氧气来促进认知加工，并且P300潜伏期受缺氧的影响大于低气压条件。意义：本研究表明，在研究低压缺氧对认知功能的影响时，ABR各组分和N100、P300潜伏期都是重要的记录。(c) 2005年国际临床神经生理学联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: This study investigated the effect of hyobaric hypoxia on cognitive function.Methods: We recorded the auditory brain-stem response (ABR) and auditory-evoked event-related potentials (ERP) in 7 male subjects during a rapid ascent to a simulated 4500 m altitude from their acclimatized altitude of 6 10 in. The amplitude and latency of each component of ABR and of ERP were assessed.Results: Compared with the values at 610 m, at 4500 in the latencies of both waves I and V of ABR significantly increased, with no change in I-V interpeak latency; and the amplitude of wave I decreased, with no change in the amplitude of wave V. The increase in altitude affected neither the amplitude nor the latency of N100. The P300 latency was prolonged significantly after exposure to hypobaric-hypoxic conditions for 2 h with no significant change in amplitude. At 4500 m, the P300 latency returned to the baseline value after oxygen was inhaled.Conclusions: Our results suggest it is possible to boost cognitive processing by supplying oxygen even when auditory Stimulus intensity decreases under hypobaric and hypoxic conditions, and that P300 latency is affected by hypoxic more than hypobaric conditions.Significance: This study demonstrated that each component of ABR and the latency of both N100 and P300 are important to record when the effects of hypobaric hypoxia on cognitive function are investigated. (c) 2005 International Federation of Clinical neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.