New pyrone and quinoline alkaloid from Almeidea rubra and their trypanocidal activity
New pyrone and quinoline alkaloid from Almeidea rubra and their trypanocidal activity
复制标题
DOI：
10.1590/s0103-50532005000300018
复制
发表时间：
2005-06-01
影响因子：
1.4
通讯作者：
Albuquerque, Sérgio de
中科院分区：
文献类型：
--
作者：
Ambrozin, Alessandra R. P.;Mafezoli, Jair;Albuquerque, Sérgio de
研究了红豆草叶片甲醇提取物的乙酸乙酯部位。圣-希尔（芸香科）分离得到两个新的化合物4-甲氧基-6-[2-（甲基氨基）苯基]-2H-吡喃2-酮和rel-（7 R，8 R）-8-[（E）-3-羟基-3-甲基-1-丁烯基]-4，8-二甲氧基-5，6，7，8-四氢呋喃并[2，3-B]喹啉-7-基乙酸酯，沿着已知的化合物树酯碱、N-甲基-1-羟基-3-甲氧基吖啶酮、茵芋碱、kokusagine、异dutaduprine、异茵芋碱、和异极草精。它们的结构是基于它们的光谱数据建立的，并且对于新化合物，这些数据在本文中描述。此外，这些化合物在克氏锥虫的三鞭毛体形式上进行了测定，显示出中等的杀锥虫活性。
\The investigation of the ethyl acetate fraction of methanol extract from leaves of Almeidea rubra A. St.-Hil. ( Rutaceae) afforded two new compounds 4-methoxy-6-[2-(methylamino)phenyl]-2H-pyran2- one and rel-(7R,8R)-8-[(E)-3-hydroxy-3-methyl-1-butenyl]-4,8-dimethoxy- 5,6,7,8-tetrahydrofuro[2,3-b]quinoline-7-yl acetate, along with the known compounds arborinine, N-methyl-1- hydroxy-3-methoxyacridone, skimmianine, kokusagine, isodutaduprine, isoskimmianine, and isokokusagine. Their structures were established based on their spectral data, and for the new compounds these data are described herein. Additionally, these compounds were assayed on the tripomastigote forms of Trypanosoma cruzi showing moderate trypanocidal activity.