Anti-inflammation performance of curcumin-loaded mesoporous calcium silicate cement
Anti-inflammation performance of curcumin-loaded mesoporous calcium silicate cement
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DOI：
10.1016/j.jfma.2017.06.005
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发表时间：
2017-09-01
影响因子：
3.2
通讯作者：
Shen, Yu-Fang
中科院分区：
文献类型：
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作者：
Chen, Yuan-Chien;Shie, Ming-You;Shen, Yu-Fang
背景/目的：硅酸钙（CS）骨水泥具有良好的生物活性，可诱导类骨磷灰石的形成。它们是骨组织工程和骨再生医学的良好生物材料。但是，它们具有可降解性，并且溶解的CS可在植入后早期引起炎症反应。本研究的目的是设计并制备载姜黄素的介孔CS（MesoCS/curcumin）骨水泥，作为减轻植入后炎症反应的策略。通过透射电子显微镜（TEM）、X射线衍射（XRD）和扫描电子显微镜（SEM）对MesoCS/姜黄素样品进行表征。结果：MesoCS/姜黄素骨水泥具有良好的生物相容性和物理性能。它们的结晶特征与MesoCS水泥非常相似。浸泡在模拟体液中后，MesoCS/姜黄素骨水泥可以形成类骨磷灰石层。结论：在MesoCS骨水泥中加入姜黄素可减轻炎症反应，但不影响MesoCS骨水泥原有的生物活性和性能。它可以为骨组织工程和骨再生医学提供一个很好的抑制植入后炎症反应的策略。版权所有（C）2017，台湾医学会.出版社：Elsevier Taiwan LLC
Background/Purpose: Calcium silicate (CS) cements have excellent bioactivity and can induce the bone-like apatite formation. They are good biomaterials for bone tissue engineering and bone regenerative medicine. However, they have degradability and the dissolved CS can cause the inflammatory response at the early post-implantation stage. The purpose of this study was to design and prepare the curcumin-loaded mesoporous CS (MesoCS/curcumin) cements as a strategy to reduce the inflammatory reaction after implantation.Methods: The MesoCS/curcumin cements were designed and prepared. The characteristics of MesoCS/curcumin specimens were examined by transmission electron microscopy (TEM), X-ray diffraction (XRD) and scanning electron microscopy (SEM). Their physical properties, biocompatibility, and anti-inflammatory ability were also evaluated.Results: The MesoCS/curcumin cements displayed excellent biocompatibility and physical properties. Their crystalline characterizations were very similar with MesoCS cements. After soaking in simulated body fluid, the bone-like apatite layer of the MesoCS/curcumin cements could be formed. In addition, it could inhibit the expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) after inflammation reaction induced by lipopolysaccharides and had good anti-inflammatory ability.Conclusion: Adding curcumin in MesoCS cements can reduce the inflammatory reaction, but does not affect the original biological activity and properties of MesoCS cements. It can provide a good strategy to inhibit the inflammatory reaction after implantation for bone tissue engineering and bone regenerative medicine. Copyright (C) 2017, Formosan Medical Association. Published by Elsevier Taiwan LLC.