Expression patterns of Wnt genes in mouse gut development
Expression patterns of Wnt genes in mouse gut development
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DOI：
10.1016/s0925-4773(01)00390-2
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发表时间：
2001-07-01
影响因子：
2.6
通讯作者：
Kemler, R
中科院分区：
文献类型：
--
作者：
Lickert, H;Kispert, A;Kemler, R
在无脊椎动物和脊椎动物的发育和成年组织中，Wnt信号调节细胞命运决定和细胞增殖。在这里，我们描述了在小鼠胚胎肠道发育中表达的Wnt基因Wnt2a、4、5a、5b、6和11的鉴定。在胚胎期(E) 12.5和胚胎发育16.5之间，这些因子在消化管的前后轴上表现出各自的特征和区域特异性表达模式。Wnt5a的表达局限于间质间室，而Wnt4的表达在肠上皮和肠系膜上均有发现。Wnt 11在食管和结肠上皮中表达，但也在胃的间充质细胞中表达。Wnt5b和Wnt6在食管上皮中表达受限。在发育中的胃中观察到特征性的区域化表达模式。Wnt5a表达于前瞻性腺体区域的间质层，但在E14.5时仅限于腺体区域的尖端。wnt11在胃食管连接处高表达，而Wnt4在胃幽门区上皮内发现，但在前腺区上皮中未发现。(C) 2001爱思唯尔科学爱尔兰有限公司版权所有。
Wnt signaling regulates cell fate decisions and cell proliferation during development and in adult tissues in both invertebrates and vertebrates. Here we describe the identification of Wnt genes, Wnt2a, 4, 5a, 5b, 6 and 11, expressed in mouse embryonic gut development. Each of these gents exhibits a characteristic and regional-specific expression pattern along the anterior-posterior axis of the digestive tube between embryonic day (E) 12.5 and 16.5 of embryonic development. The expression of Wnt5a is confined to the mesenchymal compartment, while expression of Wnt4 is found both in the intestinal epithelium and the mesenteric anlage. Wnt 11 is expressed in the epithelium of esophagus and colon, but also in mesenchymal cells of the stomach. Wnt5b and Wnt6 exhibit restricted expression in the epithelium of the esophagus. A characteristic regionalized expression pattern is observed in the developing stomach. Wnt5a is expressed in the mesenchymal layer of the prospective gland region but becomes restricted to the: tip of the gland region by E14.5. Wnt 11 is highly expressed at the gastroesophageal junctions, while Wnt4 is found in the epithelium lining the pyloric region of the stomach but not in the epithelium of the prospective gland region. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.