Prevalence and risk factors of neuropathic pain in survivors of myocardial infarction with pre-diabetes and diabetes. The KORA Myocardial Infarction Registry
Prevalence and risk factors of neuropathic pain in survivors of myocardial infarction with pre-diabetes and diabetes. The KORA Myocardial Infarction Registry
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DOI：
10.1016/j.ejpain.2008.07.007
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发表时间：
2009-07-01
影响因子：
3.6
通讯作者：
Mielck, Andreas
中科院分区：
文献类型：
--
作者：
Ziegler, Dan;Rathmann, Wolfgang;Mielck, Andreas
与神经性疼痛相关的最低血糖阈值和危险因素尚未确定。本研究的目的是确定糖尿病、糖耐量受损（IGT）、空腹血糖受损（IFG）、正常糖耐量（NGT）心肌梗死幸存者神经病理性疼痛的患病率和危险因素。年龄25-74岁的糖尿病受试者（n = 214）和年龄和性别匹配的对照组（n = 212）来自以人群为基础的KORA（奥格斯堡地区合作健康研究）心肌梗死登记处，通过密歇根神经病筛查工具使用其疼痛相关问题和>2的检查评分临界点评估神经性疼痛。在对照组中进行口服葡萄糖耐量试验。在对照组中，61例（28.8%）患有IGT（单独或合并IFG），70例（33.0%）患有单独IFG，81例患有NCT。糖尿病受试者中神经性疼痛的患病率为21.0%，IGT受试者中为14.8%，IFG受试者中为5.7%，NCT受试者中为3.7%（总体p < 0.001）。在整个研究人群（n = 426）中，年龄、腰围、外周动脉疾病（PAD）和糖尿病是与神经性疼痛显著相关的独立因素，而在糖尿病组中，腰围、体力活动和PAD（均p < 0.05）。总之，与单纯IFG和NGT患者相比，糖尿病和IGT心肌梗死幸存者神经病理性疼痛的患病率相对较高。相关的心血管危险因素，包括腹部肥胖和低体力活动可能构成的目标，以防止在这一人群中的神经性疼痛。(C)2008年，国际疼痛研究协会欧洲分会联合会。由爱思唯尔有限公司出版。保留所有权利。
The lowest glycemic threshold for and the risk factors associated with neuropathic pain have not been established. The aim of this study was to determine the prevalence and risk factors of neuropathic pain in survivors of myocardial infarction with diabetes, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), normal glucose tolerance (NGT). Subjects aged 25-74 years with diabetes (n = 214) and controls matched for age and sex (n = 212) from the population-based KORA (Cooperative Health Research in the Region of Augsburg) Myocardial Infarction Registry were assessed for neuropathic pain by the Michigan Neuropathy Screening Instrument using its pain-relevant questions and an examination score cutpoint >2. An oral glucose tolerance test was performed in the controls. Among the controls, 61 (28.8%) had IGT (either isolated or combined with IFG), 70 (33.0%) had isolated IFG, and 81 had NCT. The prevalence of neuropathic pain was 21.0% in the diabetic Subjects, 14.8% in those with IGT, 5.7% in those with IFG, and 3.7% in those with NCT (overall p < 0.001). In the entire population studied (n = 426), age, waist circumference, peripheral arterial disease (PAD), and diabetes were independent factors significantly associated with neuropathic pain, while in the diabetic group it was waist circumference, physical activity, and PAD (all p < 0.05). In conclusion, the prevalence of neuropathic pain is relatively high among survivors of myocardial infarction with diabetes and IGT compared to those with isolated IFG and NGT. Associated cardiovascular risk factors including abdominal obesity and low physical activity may constitute targets to prevent neuropathic pain in this population. (C) 2008 European Federation of Chapters of the International Association for the Study of Pain. Published by Elsevier Ltd. All rights reserved.