One month of human memory consolidation enhances retrieval-related hippocampal activity
One month of human memory consolidation enhances retrieval-related hippocampal activity
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DOI：
10.1002/hipo.20105
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发表时间：
2005-01-01
期刊：
影响因子：
3.5
通讯作者：
Henke, K
中科院分区：
文献类型：
--
作者：
Bosshardt, S;Degonda, N;Henke, K
我们研究了联想学习后1天和1个月海马在记忆检索中的作用。研究人员使用功能性磁共振成像技术记录了20名健康学生与检索相关的大脑活动，其中12名学生学习成绩好，8名学生学习成绩差。在一天的延迟中，学习能力差的学习者海马和新皮层的神经招募增强，从而达到与学习能力好的学习者相当的检索性能。在这20名受试者中，与检索相关的海马活动与一个月的记忆间隔内的遗忘之间存在正相关（活动越大，遗忘越多）。较差学习者的检索性能在日-月滞后期间显著下降，而较好的学习者则保持较高的检索性能，这表明他们是较好的记忆巩固者。他们与检索相关的海马体和新皮层的活动从一天到一个月的滞后都有所增加。当检索性能在日和月之间匹配时，以及在日和月之间匹配检索信息的学习过程时，都可以观察到这种增加。从日滞后到月滞后，任务专用神经网络活动的增加可能反映了任务需求的增加或记忆巩固过程中海马-新皮层记忆痕迹的增殖，正如多重痕迹理论所建议的那样。(c) 2005 Wiley-Liss, Inc。
We studied the role of the hippocampus in memory retrieval at 1 day and I month following associative learning of word pairs. Retrieval-related brain activity was recorded using functional magnetic resonance imaging in 20 healthy students, of which 12 were good learners and eight were poor learners. At the day lag, the poor learners exhibited enhanced neural recruitment in the hippocampus and neocortex to reach a retrieval performance comparable to that of the good learners. Over the 20 subjects, there was a positive correlation between retrieval-related hippocampal activity at the day lag and forgetting over the month retention interval (the greater the activity, the more forgetting). Although the poor learners' retrieval performance declined dramatically from the day to the month lag, the good learners maintained a high retrieval performance, which distinguishes them as good memory consolidators. Their retrieval-related hippocampal and neocortical activity increased from the day to the month lag. This increase was observed both when retrieval performance was matched between the day and the month lag and when the learning procedure for information retrieved at the day and the month lag was matched. This activity increase in the task-specialized neural network from the day lag to the month lag may reflect an increase in task demands or the proliferation of hippocampal-neocortical memory traces during memory consolidation as suggested by the multiple trace theory. (c) 2005 Wiley-Liss, Inc.