Persistent neuropathy after treatment with cisplatin and oxaliplatin
Persistent neuropathy after treatment with cisplatin and oxaliplatin
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DOI：
10.1080/02841860902806609
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发表时间：
2009-01-01
期刊：
影响因子：
3.1
通讯作者：
Schellens, Jan H. M.
中科院分区：
文献类型：
--
作者：
Brouwers, Elke E. M.;Huitema, Alwin D. R.;Schellens, Jan H. M.
背景当前探索性研究的目的是评估45例患者接受顺铂或奥沙利铂治疗后长达6年的持续性神经病变，并确定评估神经病变的最适当方法。此外，持续性神经病变的可能决定因素的影响进行了研究。材料和方法。通过问卷调查、神经功能检查和振动阈值（VT）测量进行神经病变评估。由于VT测定提供了最客观的信息，因此VT测量用于进一步分析。结果和讨论。分析显示，手部神经病变与随访时间相关，观察到的恢复半衰期为6.8（+/-3.1）年。在观察期内，未证实足神经病变的显著可逆性。对于顺铂，神经病变的严重程度与累积剂量和硫代硫酸钠的使用有关。奥沙利铂诱导的神经病变似乎与研究剂量范围内的剂量无关。未证实与铂水平、肾功能、谷胱甘肽转移酶基因型、糖尿病、饮酒或合并用药的关系。本研究是一项探索性研究，所讨论的问题需要进一步研究。
Background. The aims of the current explorative study were to assess persistent neuropathy in 45 patients up to 6 years after treatment with cisplatin or oxaliplatin and to determine the most adequate method to evaluate neuropathy. Furthermore, the effect of possible determinants on persistent neuropathy was investigated. Material and methods. The assessment of neuropathy was performed using a questionnaire, by neurological tests, and by vibration threshold (VT) measurements. Because VT determination gives the most objective information, VT measurements were used for further analyses. Results and discussion. The analyses revealed that neuropathy of the hands was related to follow-up time, with an observed recovery half-life of 6.8 (+/-3.1) years. No significant reversibility of neuropathy of the feet within the observation period could be demonstrated. For cisplatin, the severity of neuropathy was related to the cumulative dose and sodium thiosulfate use. Oxaliplatin induced neuropathy did not appear to be related to the dose within the studied dose range. No relationship with platinum levels, renal function, glutathione transferase genotypes, diabetes mellitus, alcohol use, or co-medication could be demonstrated. This study was performed as an explorative study and the issues discussed need to be investigated further.