PSEUDOEXFOLIATIVE FIBRILLOPATHY IN THE SKIN OF PATIENTS WITH OCULAR PSEUDOEXFOLIATION
PSEUDOEXFOLIATIVE FIBRILLOPATHY IN THE SKIN OF PATIENTS WITH OCULAR PSEUDOEXFOLIATION
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DOI：
10.1016/s0002-9394(14)77871-7
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发表时间：
1990-11-15
影响因子：
4.2
通讯作者：
HOEPNER, JA
中科院分区：
文献类型：
--
作者：
STREETEN, BW;DARK, AJ;HOEPNER, JA
除了在眼内发生外，还报告了结膜和睫状后动脉周围的假性剥脱性纤维病。为了确定它是否具有更广泛的眼外分布，我们研究了13例典型假性剥脱患者的皮肤活检标本的一至三个区域的超微结构。在13名患者中的11名患者中发现了与眼睛非常相似的纤维病。13名对照受试者中，只有一名患有晚期低眼压性青光眼的78岁男性患有类似的纤维病。在年龄超过70岁的假性剥脱患者中，伴随的皮肤弹性组织变性使评估变得困难，因为皮肤中的假性剥脱结节主要沿着弹性纤维出现，并且它们的形态特征似乎受到弹性组织变性过程的影响。这些结果提示，假性剥脱是一个与弹性组织变性密切相关的系统性过程，应在深部组织和内脏的弹性系统中进一步寻找假性剥脱纤维。
In addition to its occurrence within the eye, pseudoexfoliative fibrillopathy has been reported in the conjunctiva and around a posterior ciliary artery. To detemine whether it has a more diffuse extraocular distribution, we studied skin biopsy specimens ultrastructural from one to three areas in 13 patients with classic pseudoexfoliation. A fibrillopathy closely resembling that in the eye was found in 11 of the 13 patients. Only one of the 13 controls subjects, a 78-year-old man with advanced low-tension glaucoma, had a similar fibrillopathy. In the patients with pseudoexfoliation who were more than 70 years of age, the accompanying dermal elastosis made evaluation difficult, because the pseudoexfoliative nodules in the skin occur primarily along elastic fibers, and their morphologic characteristics appeared to be influenced by the elastotic process. These results suggest that pseudoexfoliation is a systemic process related closely to elastosis, and that further search for pseudoexfoliative fibers should be made in the elastic system of the deep tissues and internal organs.