Influence of citalopram and environmental temperature on exercise-induced changes in BDNF
Influence of citalopram and environmental temperature on exercise-induced changes in BDNF
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DOI：
10.1016/j.neulet.2011.03.001
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发表时间：
2011-04-25
影响因子：
2.5
通讯作者：
Meeusen, Romain
中科院分区：
文献类型：
--
作者：
Goekint, Maaike;Roelands, Bart;Meeusen, Romain
目的：已知血清脑源性神经营养因子（BDNF）随运动而增加。这种增加被认为源于大脑，并提出单胺类参与BDNF调节。热暴露可能会影响大脑中BDNF的输出。因此，我们假设选择性5 -羟色胺再摄取抑制剂可以影响运动诱导的BDNF的增加，并且当在高温下进行运动时，外周BDNF会更高。方法：11名训练有素的男性在18℃或30℃的环境温度下，使用西italopram或安慰剂治疗（20mg / 12h），在循环测力仪上进行4项实验，分别在休息时、在55% W（最大）下60分钟后、在75% W（最大）下计时30分钟后和恢复15分钟后，在4个时间点采集血液样本（BDNF和皮质醇）。测量心率和核心温度。结果：30℃时的计时赛成绩比18℃时差20% (p < 0.01)，不受西酞普兰的影响。西酞普兰组血清BDNF降低，基础皮质醇升高（p < 0.05）。运动引起BDNF和皮质醇的增加（p < 0.001）。在运动过程中，BDNF与核心温度遵循相同的模式，在30摄氏度时，这两个变量的水平都较高。与温带条件相比，皮质醇在30摄氏度时也有所增加（p < 0.01）。结论：运动引起血清BDNF和皮质醇升高。这种增加在高温下的运动中得到加强。由于血脑屏障的渗透性随着高温运动的增加而增加，因此提出了这导致脑内BDNF输出增加的假设。5 -羟色胺能刺激并没有增加外周BDNF，西酞普兰组的BDNF甚至更低。未来的研究应该集中在BDNF随运动增加的机制上。2011爱思唯尔爱尔兰有限公司版权所有。
Purpose: serum brain-derived neurotrophic factor (BDNF) is known to increase with exercise. This increase is believed to originate from the brain and it is suggested that monoamines are involved in BDNF regulation. Heat exposure could influence the supposed BDNF output from the brain. Therefore, we hypothesized that administration of a selective serotonin reuptake inhibitor could influence the exercise-induced increase in BDNF, and that peripheral BDNF will be higher when exercise is performed in the heat. Methods: Eleven well-trained males performed 4 experimental trials on a cycle ergometer with citalopram or placebo treatment (20 mg in 12 h) in an environmental temperature of 18 degrees C or 30 degrees C. Blood samples (BDNF and cortisol) were taken at 4 time points: at rest, after 60 min at 55% W(max), after a time trial of 30 min at 75% W(max) and following 15 min of recovery. Heart rate and core temperature were measured. Results: Performance on the time trial was 20% worse in 30 degrees C compared to 18 degrees C (p < 0.01), without influence of citalopram. Serum BDNF was found to be lower under citalopram treatment, while basal cortisol levels were increased (p < 0.05). Exercise triggered an increase in both BDNF and cortisol (p < 0.001). BDNF followed the same pattern as core temperature during exercise, with higher levels of both variables in 30 degrees C. Cortisol was also increased in 30 degrees C compared to temperate conditions (p < 0.01). Conclusion: Exercise caused a rise in serum BDNF and cortisol. This increase was enhanced with exercise in the heat. Since permeability of the blood-brain barrier increases with exercise in the heat, the hypothesis was raised that this causes a higher cerebral output of BDNF. Serotonergic stimulation did not increase peripheral BDNF, which was even lower with citalopram administration. Future research should focus on mechanisms behind BDNF increase with exercise. (C) 2011 Elsevier Ireland Ltd. All rights reserved.