Changes in cardiopulmonary exercise testing parameters following continuous flow left ventricular assist device implantation and heart transplantation.
Changes in cardiopulmonary exercise testing parameters following continuous flow left ventricular assist device implantation and heart transplantation.
复制标题
DOI:
10.1016/j.cardfail.2014.05.008
复制
发表时间:
2014-08
影响因子:
6
通讯作者:
Pereira, Naveen L.
中科院分区:
文献类型:
--
作者:
Dunlay, Shannon M.;Allison, Thomas G.;Pereira, Naveen L.
Reduced exercise tolerance from impaired cardiac output is an important criterion for left ventricular assist device (LVAD) implantation. However, little is known about how exercise capacity changes following LVAD, and how changes compare with patients undergoing heart transplant. We compared changes in cardiopulmonary exercise testing performed pre- and post-operatively in patients who underwent HeartMate II LVAD implantation (n=25) and heart transplantation (n=74) at the Mayo Clinic in Rochester, Minnesota from 2007–2012. Pre-operatively, patients undergoing LVAD and transplant had markedly reduced exercise time (mean 5.1 minutes [45% predicted] and 5.0 minutes [44% predicted], respectively), low peak VO2 (mean 11.5 ml/kg/min [43% predicted] and 11.9 mL/kg/min [38% predicted]), and abnormal ventilatory gas exchange (VE/VCO2 nadir 39.4 and 37.4). Following LVAD and transplant, there were similar improvements in exercise time (mean Δ +1.2 vs. 1.7 minutes, respectively, p=0.27) and VE/VCO2 nadir (mean Δ −3.7 vs. −4.2, p=0.74). However, peak VO2 increased post-transplant but did not change post-LVAD (mean Δ +5.4 vs. +0.9 mL/kg/min, respectively, p<0.001). Most patients (72%) had a peak VO2<14 mL/kg/min post-LVAD. While improvements in exercise capacity and gas exchange are seen following LVAD and heart transplant, peak VO2 doesn’t improve post-LVAD and remains markedly abnormal in most patients.
登录
查看更多内容
DOI:
10.1016/j.healun.2011.04.012
发表时间:
2011-10
期刊:
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
影响因子:
--
作者:
Raichlin E;Al-Omari MA;Hayes CL;Edwards BS;Frantz RP;Boilson BA;Clavell AL;Rodeheffer RJ;Schirger JA;Kushwaha SS;Allison TG;Pereira NL
通讯作者:
Pereira NL
影响因子:
2.8
作者:
Daida, H;Allison, TG;Gau, GT
通讯作者:
Gau, GT
影响因子:
18.2
作者:
Jakovljevic, Djordje G.;Birks, Emma J.;Brodie, David A.
通讯作者:
Brodie, David A.
DOI:
10.1161/circheartfailure.111.966366
发表时间:
2012-11
期刊:
Circulation. Heart failure
影响因子:
--
作者:
Dunlay SM;Roger VL;Weston SA;Jiang R;Redfield MM
通讯作者:
Redfield MM
影响因子:
4.2
作者:
Leibner, Evan S.;Cysyk, Joshua;Pae, Walter E.
通讯作者:
Pae, Walter E.