The selective appetite for Na+ shown by Na+‐deficient sheep
The selective appetite for Na+ shown by Na+‐deficient sheep
复制标题
缺Na+的羊表现出对Na+的选择性食欲
DOI：
10.1113/jphysiol.1961.sp006708
复制
发表时间：
1961
期刊：
影响因子：
--
通讯作者：
J. Sabine
中科院分区：
文献类型：
--
作者：
D. Denton;J. Sabine
鉴于Na+平衡对高等物种正常功能的重要性，在Na+缺乏的情况下，促进Na+摄入的先天行为模式可能会给生物体带来重要的生存优势。Richter（1956）指出，幼鼠的唯一营养来源是母奶，当它们第一次接触氯化钠时，始终表现出对氯化钠的强烈食欲。他说，哺乳动物普遍喜欢氯化钠，他认为这是一种遗传行为模式的指示，这种行为模式赋予了生存优势。这种对盐的原始吸引力被代谢条件所改变，正如肾上腺切除术导致盐损失时NaCl溶液摄入量增加所证明的那样。该实验室以前的出版物描述了患有永久性单侧腮腺瘘的绵羊的制备和维持（Denton, 1956, 1957 a; Denton, Goding & Wright, 1959），并失去了1-41。含有170-680 m当量NaHCO3的碱性腮腺唾液。以这种方式制备的动物是研究面对内部环境受控和精确定义的压力时的生理适应的极好对象。本文报道了羊对含钠溶液自愿摄入的实验，以及唾液流失引起的Na+缺乏对其自愿摄入的影响。
In view of the importance of Na+ equilibrium to normal function of higher species, an innate behaviour pattern promoting its intake in the face of deficiency could give an important survival advantage to the organism. Richter (1956) has shown that young rats, for whom their mother's milk has been the sole source of nourishment, consistently showed an active appetite for NaCl when confronted with it for the first time. He states that with mammals there is a universal liking for NaCl, and he considers this to be indicative of an inherited behaviour pattern which has conferred survival advantage. Thisprimitive attractionfor saltwas modified by metabolic conditions, as is evidenced by the increased intake of NaCl solution which occurred when NaCl loss was caused by adrenalectomy. Previous publications from this laboratory have described the preparation and maintenance of sheep which have a permanent unilateral parotid fistula (Denton, 1956, 1957 a; Denton, Goding & Wright, 1959), and lose 1-41./day of alkaline parotid saliva containing 170-680 m-equiv of NaHCO3. An animal prepared in this manner is an excellent subject for the study of physiological adaptations in the face of a controlled and precisely defined stress on the milieu interieur. This paper reports experiments on the voluntary intake by sheep of Na-containing solutions, and the effect of Na+ deficiency caused by loss of saliva on this voluntary intake.