Simulation of diagnostic ultrasound image pulse sequences in cavitation bioeffects research
Simulation of diagnostic ultrasound image pulse sequences in cavitation bioeffects research
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DOI：
10.1121/1.2773991
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发表时间：
2007-10-01
影响因子：
2.4
通讯作者：
Wiggins, Roger C.
中科院分区：
文献类型：
--
作者：
Miller, Douglas L.;Dou, Chunyan;Wiggins, Roger C.
诊断超声（DUS）空化生物效应的研究通常涉及诊断扫描仪作为暴露源。然而，这会限制用于实验的曝光参数的范围。将麻醉的无毛大鼠固定在水浴中，并将其右肾暴露于超声。用高斯包络幅度调制模拟诊断扫描产生的图像脉冲序列。在1-5分钟曝光期间给予10 μ l/kg/min的静脉内剂量的Deadly（R）造影剂。通过组织学评估肾小球毛细血管出血。静态暴露近似于DUS在射束区域内引起的生物效应。然而，使用五次紧密间隔的曝光更忠实地再现了在DUS扫描平面内产生的总效果。以Is间隔递送的单脉冲引起与模拟DUS相同的效果。将100 ins三角波调制用于IPS的斜升或斜降分别没有效果或效果很大。最后，一个空气背衬换能器模拟DUS没有造影剂显示出零效应，即使在目前的DUS指南上限的两倍。相对简单的单元件实验室暴露系统可以模拟诊断超声暴露，并允许探索超出当前临床系统可用的参数范围。(C)2007年，美国声学学会。
Research on cavitational bioeffects of diagnostic ultrasound (DUS) typically involves a diagnostic scanner as the exposure source. However, this can limit the ranges of exposure parameters for experimentation. Anesthetized hairless rats were mounted in a water bath and their right kidneys were exposed to ultrasound. Amplitude modulation with Gaussian envelopes simulated the image pulse sequences (IPSs) produced by diagnostic scanning. A 10 mu l/kg/min IV dose of Definity(R) contrast agent was given during 1-5 min exposures. Glomerular capillary hemorrhage was assessed by histology. A stationary exposure approximated the bioeffects induced by DUS within the beam area. However, the use of five closely spaced exposures more faithfully reproduced the total effect produced within a DUS scan plane. Single pulses delivered at I s intervals induced the same effect as the simulated DUS. Use of 100 ins triangle-wave modulations for ramp-up or ramp-down of the IPS gave no effect or a large effect, respectively.. Finally, an air-backed transducer simulating DUS without contrast agent showed a zero effect even operating at twice the present DUS guideline upper limit. Relatively simple single-element laboratory exposure systems can simulate diagnostic ultrasound exposure and allow exploration of parameter ranges beyond those available on present clinical systems. (C) 2007 Acoustical Society of America.