The ubiquitin system, disease, and drug discovery.
The ubiquitin system, disease, and drug discovery.
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泛素系统，疾病和药物发现。
DOI：
10.1186/1471-2091-9-s1-s7
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发表时间：
2008-10-21
期刊：
影响因子：
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通讯作者：
Petroski, Matthew D.
中科院分区：
文献类型：
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作者：
Petroski, Matthew D.
蛋白质修饰的泛蛋白系统已成为参与调节多种细胞过程的重要机制。随着我们对这个系统中的通路的了解的增加，蛋白质泛素和人类疾病之间的联系也在增加。2003年FDA批准蛋白酶体抑制剂万珂后，泛素系统的治疗功效得到了充分发挥。目前在泛素系统中的药物发现活动寻求（i）扩大具有不同作用机制和改善的生物利用度的新蛋白酶体抑制剂的开发，以及（ii）验证新靶点。这篇综述总结了我们目前对泛素系统在各种人类疾病中的作用的认识，这些疾病包括癌症、病毒感染和神经退行性疾病、肌肉萎缩、糖尿病和炎症。我提供了一个介绍泛素系统，突出一些新兴的泛素系统和疾病之间的关系，并讨论当前和未来的努力，利用这个潜在的强大的系统，以改善人类健康的各个方面。从Current BioData的靶向蛋白质数据库（TPdb;）重新发布。
The ubiquitin system of protein modification has emerged as a crucial mechanism involved in the regulation of a wide array of cellular processes. As our knowledge of the pathways in this system has grown, so have the ties between the protein ubiquitin and human disease. The power of the ubiquitin system for therapeutic benefit blossomed with the approval of the proteasome inhibitor Velcade in 2003 by the FDA. Current drug discovery activities in the ubiquitin system seek to (i) expand the development of new proteasome inhibitors with distinct mechanisms of action and improved bioavailability, and (ii) validate new targets. This review summarizes our current understanding of the role of the ubiquitin system in various human diseases ranging from cancer, viral infection and neurodegenerative disorders to muscle wasting, diabetes and inflammation. I provide an introduction to the ubiquitin system, highlight some emerging relationships between the ubiquitin system and disease, and discuss current and future efforts to harness aspects of this potentially powerful system for improving human health. Republished from Current BioData's Targeted Proteins database (TPdb; ).