A novel mannose containing phenolic glycolipid from Mycobacterium kansasii.
A novel mannose containing phenolic glycolipid from Mycobacterium kansasii.
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一种新型甘露糖，含有来自堪萨斯分枝杆菌的酚糖脂。
DOI：
10.1016/s0021-9258(18)48108-2
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
G. Puzo
中科院分区：
文献类型：
--
作者：
M. Rivière;J. Fournié;G. Puzo
利用高效液相色谱法，从堪萨斯分枝杆菌（Mycobacterium kansasii）的一个粗提物中分离到一种新的酚糖脂，称为酚糖脂-II。通过快原子轰击质谱和质子核磁共振谱确定其结构为：2，4-di-O-Me-alpha-D-Manp（1-3）4-O-Ac-2-O-Me-alpha-L-Fucp（1-3）2-O-Me-alpha-L-Rhap（1-3）2，4-di-O-Me-alpha-L-Rhap 1-phenolphthiocerol dimycerosate。酚糖脂I和II的区别仅在于它们的远端单糖半抗原，其分别是2，6-二脱氧-4-O-Me-α-D-阿拉伯糖己吡喃糖基和2，4-二-O-Me-α-D-甘露吡喃糖基。这种糖似乎是分枝杆菌属中特有的。此外，酚糖脂I和II与脂寡糖一起构成了M的两类抗原。堪萨斯。
Using high-performance liquid chromatography, a new kind of phenolic glycolipid quantitatively minor, called phenolic glycolipid-II, was isolated from a lipidic fraction of Mycobacterium kansasii. The structure was determined by fast atom bombardment-mass spectrometry and proton nuclear magnetic resonance spectroscopy, as: 2,4-di-O-Me-alpha-D-Manp(1—3) 4-O-Ac-2-O-Me-alpha-L-Fucp(1—3)2-O-Me- alpha-L-Rhap(1—3) 2,4-di-O-Me-alpha-L-Rhap 1—phenolphthiocerol dimycocerosate. Phenolic glycolipids I and II differ only by their distal monosaccharide hapten which is 2,6-dideoxy-4-O-Me-alpha-D-arabinohexopyranosyl and the 2,4-di-O-Me-alpha-D-mannopyranosyl, respectively. This sugar appears to be characteristic and apparently unique in the Mycobacterium genus. Moreover, phenolic glycolipids I and II constitute with the lipooligosaccharides two classes of antigens of M. kansasii.