Graphical analysis of PET data applied to reversible and irreversible tracers
Graphical analysis of PET data applied to reversible and irreversible tracers
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DOI：
10.1016/s0969-8051(00)00137-2
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发表时间：
2000-10-01
影响因子：
3.1
通讯作者：
Logan, J
中科院分区：
文献类型：
--
作者：
Logan, J
房室分析的微分方程形成了描述成像研究中使用的示踪剂摄取的模型的基础。图解分析将模型方程转换成线性图，线性图的斜率表示示踪剂结合的测量。图解方法不依赖于特定的模型结构，但是如果假设模型结构，则斜率可以与模型参数的组合相关，所需的输入是来自感兴趣区域的摄取数据与时间的关系，并且输入函数可以是血浆测量值或来自感兴趣区域的摄取数据。合适参考区域。图形方法可应用于可逆和不可逆结合示踪剂。它们提供了相当容易的计算相比，在一般用于描述示踪剂的结合的微分方程的解决方案中的单个模型参数的优化。考虑了图形技术适用的条件以及分离示踪剂递送和绑定时遇到的一些问题。此外，噪声的影响可以在分布体积中引入偏差，其是可逆示踪剂的图形分析的斜率。平滑技术可以最小化这个问题并保持模型独立性。在任何情况下，图形技术都可以以可视化的方式提供对示踪剂结合动力学的洞察。核医学生物学27;7：661-670，2000。(C)2000 Elsevier Science Inc，保留所有权利。
The differential equations of compartmental analysis form the basis of the models describing the uptake of tracers used in imaging studies. Graphical analyses convert the model equations into linear plots, the slopes of which represent measures of tracer binding, The graphical methods are not dependent upon a particular model structure but the slopes can be related to combinations of the model parameters if a model structure is assumed, The input required is uptake data from a region of interest vs time and an input function that can either be plasma measurements or uptake data from a suitable reference region. Graphical methods can be applied to both reversible and irreversibly binding tracers. They provide considerable ease of computation compared to the optimization of individual model parameters in the solution of the differential equations generally used to describe the binding of tracers. Conditions under which the graphical techniques are applicable and st,me problems encountered in separating tracer delivery and binding are considered. Also the effect of noise can introduce a bias in the distribution volume which is the slope of the graphical analysis of reversible tracers. Smoothing techniques may minimize this problem and retain the model independence. In any case graphical techniques can provide insight into the binding kinetics of tracers in a visual way. NUCL MED BIOL 27;7:661-670, 2000. (C) 2000 Elsevier Science Inc, All rights reserved.