Increased total body extracellular-to-intracellular water ratio in community-dwelling elderly women is associated with decreased handgrip strength and gait speed
Increased total body extracellular-to-intracellular water ratio in community-dwelling elderly women is associated with decreased handgrip strength and gait speed
复制标题
DOI：
10.1016/j.nut.2021.111175
复制
发表时间：
2021-02-23
期刊：
影响因子：
4.4
通讯作者：
Nagahiro, Shinji
中科院分区：
文献类型：
--
作者：
Hioka, Akemi;Akazawa, Naoki;Nagahiro, Shinji
目的：由于老年人大腿的细胞外/细胞内水(ECW/ICW)比值与膝关节伸展力量或步速呈负相关，老年人全身ECW/ICW比值的增加被认为与身体机能的下降有关。然而，这些关系还没有得到适当的调查。本研究的目的是探讨社区老年妇女握力和步速与全身ECW/ICW比值的关系。我们招募了71名65岁的社区居住妇女，她们可以独立进行日常生活活动。用生物电阻抗法测量全身ECW/ICW比值。用皮尔逊相关系数评估全身ECW/ICW比值与握力和步速的关系。此外，逐步多元回归分析被用来确定与握力和步速独立相关的因素。被考虑的自变量是全身ECW/ICW比率、年龄、体重指数、用药次数、有无疼痛和某些病史。结果：结果显示，社区老年妇女全身ECW/ICW比率增加与握力和步速下降有关。此外，即使在调整混杂因素后，全身ECW/ICW比率仍与握力显著相关。结论：全身ECW/ICW比率可能反映社区老年妇女的健康状况。(C)2021 Elsevier Inc.保留所有权利。
Objective: As the extracellular-to-intracellular water (ECW/ICW) ratio of the thigh is negatively associated with knee extension strength or gait speed in the elderly, an increase in the total body ECW/ICW ratio in the elderly is considered to be related to a decrease in physical function. However, these relationships have not been properly investigated. The aim of this study was to investigate the relationship of handgrip strength and gait speed with the total body ECW/ICW ratio in community-dwelling elderly women.Methods: The present study used a cross-sectional design. We enrolled 71 community-dwelling women, >65 y of age, who could independently perform activities of daily living. The total body ECW/ICW ratio was measured using bioelectrical impedance analysis. Relationships between the total body ECW/ICW ratio and grip strength and gait speed were assessed using Pearson's correlation coefficient. Additionally, stepwise multiple regression analysis was used to identify the factors that were independently associated with handgrip strength and gait speed. The independent variables considered were the total body ECW/ICW ratio, age, body mass index, number of medications, presence of pain, and a history of certain conditions.Results: The results indicated that an increased total body ECW/ICW ratio in community-dwelling elderly women was associated with a decreased handgrip strength and gait speed. Furthermore, the total body ECW/ICW ratio was significantly, independently associated with handgrip strength even after adjusting for confounding factors.Conclusion: These findings suggest that the total body ECW/ICW ratio may indicate health conditions in community-dwelling elderly women. (c) 2021 Elsevier Inc. All rights reserved.