Maternal effects on early-life gut microbiota maturation in a wild nonhuman primate
Maternal effects on early-life gut microbiota maturation in a wild nonhuman primate
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DOI：
10.1016/j.cub.2022.08.037
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发表时间：
2022-10-24
期刊：
影响因子：
9.2
通讯作者：
Lu, Amy
中科院分区：
文献类型：
--
作者：
Baniel, Alice;Petrullo, Lauren;Lu, Amy
生命早期的微生物定植是塑造宿主生理学、1-3免疫力、4-6和人类长期健康结果7 -10的重要过程。然而，我们对这一动态过程的理解在野生动物中仍然缺乏研究，11-13在生态和进化相关的背景下可以更好地理解发育机制。图12使用野生灵长类动物--狮尾狒狒最大的发育数据集之一（狮尾猿）-我们使用16 S rRNA扩增子测序来表征出生后头3年肠道微生物群的成熟，并评估母体效应的作用在塑造后代微生物群组装方面。与最近关于黑猩猩的数据相反，狒狒出生后的微生物定植与人类高度相似：14微生物α多样性在出生后迅速增加，随后组成逐渐变化，直到断奶。与断奶相关的饮食变化（从牛奶到植物性饮食）是分类组成和微生物预测功能途径转变的主要驱动力。母体效应也是影响后代肠道菌群的重要因素。在哺乳期间（18个月），幼年微生物群的组成往往更类似于母体微生物群，而不是其他成年雌性的微生物群，这表明即使在哺乳终止后，母体效应也可能持续存在。15，16总之，我们的研究结果突出了早期肠道定植的动态性质以及母体效应在塑造野生灵长类动物这一轨迹中的作用。
Early-life microbial colonization is an important process shaping host physiology,1-3 immunity,4-6 and long-term health outcomes7-10 in humans. However, our understanding of this dynamic process remains poorly investigated in wild animals,11-13 where developmental mechanisms can be better understood within ecolog-ical and evolutionarily relevant contexts.11,12 Using one of the largest developmental datasets on a wild primate-the gelada (Theropithecus gelada)-we used 16S rRNA amplicon sequencing to characterize gut microbiota maturation during the first 3 years of life and assessed the role of maternal effects in shaping offspring microbiota assembly. In contrast to recent data on chimpanzees, postnatal microbial colonization in geladas was highly similar to humans:14 microbial alpha diversity increased rapidly following birth, followed by gradual changes in composition until weaning. Dietary changes associated with weaning (from milk-to plant-based diet) were the main drivers of shifts in taxonomic composition and microbial predicted functional pathways. Maternal effects were also an important factor influencing the offspring gut microbiota. During nursing (18 months), the composition of the juvenile microbiota tended to be more similar to the maternal microbiota than to the microbiota of other adult females, highlighting that maternal effects may persist even after nursing cessation.15,16 Together, our findings highlight the dynamic nature of early -life gut colonization and the role of maternal effects in shaping this trajectory in a wild primate.