Multimodal Imaging Correlation of the Concentric Macular Rings Sign in Foveal Hypoplasia
Multimodal Imaging Correlation of the Concentric Macular Rings Sign in Foveal Hypoplasia
复制标题
DOI：
10.1016/j.oret.2020.03.022
复制
发表时间：
2020-09-01
影响因子：
4.5
通讯作者：
Denis, Daniele
中科院分区：
文献类型：
--
作者：
Ramtohul, Prithvi;Comet, Alban;Denis, Daniele
目的：扩大黄斑中心凹低眼底摄影中同心黄斑环(CMR)征的多模式成像相关性。设计：回顾性病例系列。参与者：32例黄斑中心凹发育不全患者，他们在超宽视野眼底照相上显示同心黄斑环(CMR)征。方法：纳入标准为在超宽视野眼底照相上发现同心黄斑环(CMR)征。主要观察指标：无创多模式视网膜成像，包括超宽视野眼底摄影、结构OCT、近红外反射和蓝眼底自发荧光。结果：32例患者在超宽视野眼底照相上均有CMR征象。结构OCT扫描结果与所有患者的黄斑中心凹发育不良一致。在Henle纤维层水平获得的面部OCT图像突出了初始中心凹位置周围类似的同心环。在黄斑的任何其他层面都看不到一系列同心圆环。最大外环水平直径与黄斑中心凹发育不良分级有显著相关性(P<；0.0001)。结论：超宽视野眼底成像的CMR征象可能是黄斑中心凹发育不良的一个显著特征，可以支持这种诊断，特别是在不能进行OCT检查的患者(固定不良或眼球震颤或幼儿)。多模式成像相关表明，这些同心环仅出现在Henle纤维层的水平上。这种独特的Henle纤维层几何形状可能反映了中心凹成熟时间线上的一个停滞发展阶段。(C)2020年由美国眼科学会颁发。
Purpose: To expand the multimodal imaging correlation of the concentric macular rings (CMR) sign seen on ultra-widefield fundus photography in patients with foveal hypoplasia.Design: Retrospective case series.Participants: Thirty-two patients with foveal hypoplasia who demonstrated the CMR sign on ultra-widefield fundus photography.Methods: Inclusion criterion was the presence of a CMR sign detected on ultra-widefield fundus photography.Main Outcome Measures: Noninvasive multimodal retinal imaging, including ultra-widefield fundus photography, structural OCT, near-infrared reflectance, and blue fundus autofluorescence, were investigated. Horizontal dense B-scans and en face OCT images were acquired.Results: Evaluation of all patients (n = 32 patients) demonstrated a CMR sign on ultra-widefield fundus photography. Structural OCT scans were consistent with foveal hypoplasia in all patients. En face OCT images acquired at the level of the Henle fiber layer highlighted similar concentric rings around the location of the incipient fovea. The series of concentric rings was not visible at any other level of the macula. A significant correlation was found between the horizontal diameter of the largest outer ring and foveal hypoplasia grades (P < 0.0001).Conclusions: The CMR sign seen on ultra-widefield fundus imaging may be a distinctive feature of foveal hypoplasia and can support this diagnosis, especially in patients in whom OCT cannot be performed (patients with poor fixation or nystagmus or young children). Multimodal imaging correlation suggests that these concentric rings occur exclusively at the level of the Henle fiber layer. This distinctive Henle fiber layer geometry may reflect an arrested development stage in the timeline of foveal maturation. (C) 2020 by the American Academy of Ophthalmology.