Botanical Drugs as an Emerging Strategy in Inflammatory Bowel Disease: A Review.
Botanical Drugs as an Emerging Strategy in Inflammatory Bowel Disease: A Review.
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DOI：
10.1155/2015/179616
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发表时间：
2015
影响因子：
4.6
通讯作者：
Galvez J
中科院分区：
文献类型：
--
作者：
Algieri F;Rodriguez-Nogales A;Rodriguez-Cabezas ME;Risco S;Ocete MA;Galvez J
克罗恩病和溃疡性结肠炎是两种最常见的炎症性肠病(IBD)，其特征是慢性肠道炎症，这构成了患者的生活质量，需要持续的药物和手术治疗。由于它们的病因学还不完全清楚，非完全有效的药物已经被开发出来，那些显示有效的药物并不是没有损害其长期使用的相当重要的不良反应。因此，许多患者尝试使用一些植物药，经过多年的使用，这些药物是安全有效的。然而，有必要对这些疗法进行适当的评估，以考虑治疗人类IBD的新策略。在这份报告中，我们综述了已在临床试验中对人类IBD进行评估的主要植物药物，以及其有益作用的机制和活性化合物。
Crohn's disease and ulcerative colitis are the two most common categories of inflammatory bowel disease (IBD), which are characterized by chronic inflammation of the intestine that comprises the patients' life quality and requires sustained pharmacological and surgical treatments. Since their aetiology is not completely understood, nonfully efficient drugs have been developed and those that show effectiveness are not devoid of quite important adverse effects that impair their long-term use. Therefore, many patients try with some botanical drugs, which are safe and efficient after many years of use. However, it is necessary to properly evaluate these therapies to consider a new strategy for human IBD. In this report we have reviewed the main botanical drugs that have been assessed in clinical trials in human IBD and the mechanisms and the active compounds proposed for their beneficial effects.