All in the family: TGF-beta family action in testis development.
All in the family: TGF-beta family action in testis development.
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DOI：
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发表时间：
2006
期刊：
影响因子：
3.8
通讯作者：
C. Itman;S. Mendis;B. Barakat;K. Loveland
中科院分区：
文献类型：
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作者：
C. Itman;S. Mendis;B. Barakat;K. Loveland
为了达到和维持生育能力，成年哺乳动物的睾丸产生许多代精子。虽然睾丸的完整性在胎儿时期就已建立，并在青少年时期进一步发育，但精子的产生要到很晚的时候，即青春期开始后才开始。来自转化生长因子β超家族的蛋白质的信号是至关重要的睾丸发育和精子发生的治理，这篇综述讨论了我们目前的理解的机制和过程中，他们已经牵连的胎儿和青少年睾丸的重点。
To achieve and maintain fertility, the adult mammalian testis produces many generations of sperm. While testicular integrity is established in the fetus and develops further in juvenile life, sperm production does not ensue until much later in life, following the onset of puberty. Signals from the transforming growth factor-beta superfamily of proteins are vital for governance of testis development and spermatogenesis, and this review discusses our current understanding of the mechanisms and processes in which they have been implicated with a focus on the fetal and juvenile testis.